1.D.81. The Synthetic Tetrapeptide Amphiphile (TPA) Family
Basak et al. 2017 reported a minimalistic tetrapeptide amphiphile (MPA1), derived from alanine and aminopicolinic acid that forms cation selective pores in lipid bilayers. A dimeric structure appears to form the ion-transporting pore. The pore shows a preference for Na+ owing to the oligoether chain at the C-terminus. These tetrapeptide scaffolds have a long open lifetime. Such small peptides containing pyridine can potentially be utilized for pH modulated ion transport. The basic scaffold is shown below.