1.D.97. The Diketal Mannitol Anion Channel (DKM-AC) Family
DKM forms hydrogen-bonded, cyclic, rosette-motif, self-assembled anion channels consisting of 3 - 4 DKM units forming transmembrane channels with halide selectivity and a preference order: Cl- > Br- > I- (Saha et al. 2014). The anions probably 'hop' from one unit to another through a channel that appears to have an inner diameter of 3.06 Å, a value that is close to the diameter of a dehydrated Cl-. Thus, the transmembrane channel consists of a stack of cyclic rosettes stabilized by a balance between hydroophilic H-bonding interactions and hydrophobic interactions between the cyclohexyl side chains and the lipid bilayer (Gale et al. 2017).