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1.E.1.1.3
Holin of 68 aas and 1 TMS.  Deleting the lysis module, encoding the holin, lysin and two spanins, increases outer membrane vesicle (OMV) production, suggesting that during evolution this operon has been domesticated to regulate vesiculation, possibly through the elimination of non-recyclable peptidoglycan fragments (Pasqua et al. 2021). The expression of the lysis module is negatively regulated by environmental stress stimuli as high osmolarity, low pH and low temperature (Pasqua et al. 2021).

Accession Number:O48430
Protein Name:Putative holin protein S
Length:68
Molecular Weight:7626.00
Species:Bacteriophage H19B [69932]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate endolysin, small molecules

Cross database links:

Pfam: PF04971   

References (2)

[1] “Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release.”  Neely M.N.et.al.   9680214
[2] “Arrangement and functional identification of genes in the regulatory region of lambdoid phage H-19B, a carrier of a shiga-like toxin.”  Neely M.N.et.al.   9858702

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKITTGVSY TTSAVGTGYW LLQLLDKVSP SQWVAIGVLG SLLFGLLTYL TNLYFKIRED 
61:	RRKAVRGE