TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.E.2.1.1









Lysis protein S of phage lambda, holin S105.  The lambda-holin protein can mediate a caspase-independent non-apoptotic mode of cell death (Agu et al. 2007).  Topological class I with three TMSs.  The N-terminus is outside and the C-terminus is inside (Graschopf and Bläsi 1999; Gründling et al. 2000).  Nearly identical to the holin of Shigella phage Sf6 (Dover et al. 2016).

Viruses
Caudovirales
Lysis protein S (105 aas; spP03705)
1.E.2.1.2









Lysis protein 13, gp65 of enterobacterial phage P22.

Viruses
Caudovirales
Lysis protein 13 (108 aas; spP09962)
1.E.2.1.3









Hypothetical lysis protein
Bacteria
Proteobacteria
Hypothetical lysis protein (118 aas; spP44188)
1.E.2.1.4









Hol-1 of lysogenic Xenorhabdus nematophila (Brillard et al., 2003)
Bacteria
Proteobacteria
Hol-1 of lysogenic Xenorhabdus nematophila (CAB58444)
1.E.2.1.5









Putative holin

Bacteria
Proteobacteria
Putative holin of Pseudomonas syringae
1.E.2.1.6









Putative holin

Bacteria
Proteobacteria
Putative holin of Klebsiella oxytoca
1.E.2.1.7









Putative holin

Bacteria
Proteobacteria
Putative holin of Pantoea sp.
1.E.2.1.8









Putative holin

Bacteria
Proteobacteria
Putative holin of Actinobacillus succinogenes
1.E.2.1.9









Putative phage-like holin of 112 aas and 3 TMSs

Bacteria
Proteobacteria
putative holin of Hamiltonella defensa subsp. Acyrthosiphon pisum
1.E.2.1.10









Holin of 108 aas; the gene is in a prophage genome adjacent to genes encouding a lysozyme inhibitor and a lytic protein.

Bacteria
Proteobacteria
Holin of E. coli
1.E.2.1.11









Holin (N-terminal 100 aas) fused to a D-alanyl-D-alanine carboxypeptidase (C-terminal 138 aas).  The protein is 238 aas in length with 3 N-terminal TMSs.

Bacteria
Proteobacteria
Fusion holin of Serratia odorifera
1.E.2.1.12









Putative holin of 96 aas and 3 TMSs.

Bacteria
Proteobacteria
Holin of Acinetobacter proteolyticus
1.E.2.1.13









Holin, lambda family, of 108 aas and 3 TMSs, ChiW (Hamilton et al. 2014). It is involved (possibly indirectly) in chitinase secretion (Costa et al. 2019).

Bacteria
Proteobacteria
Holin of Serratia marcescens
1.E.2.1.14









Holin of 110 aas and 3 TMSs (Czajkowski 2019).

Bacteria
Proteobacteria
Holin of Pectobacterium zantedeschiae
1.E.2.2.1









Helicobacter phage 1961P holin_3 superfamily protein

Viruses
Caudovirales
Helicobacter phage 1961P holin
1.E.2.2.2









Putative holin

Bacteria
Proteobacteria
Putative holin of Campylobacter concisus
1.E.2.2.3









Putative holin

Bacteria
Proteobacteria
Putative holin of Campylobacter jejuni
1.E.2.2.4









Putative holin

Bacteria
Proteobacteria
Putative holin of Arcobacter butzleri
1.E.2.3.1









Phage-holin-3 superfamily (CDD) member of 72 aas and possibly 1-2 TMSs.  Therre were no obvious homologues in the NCBI database as of 3/3/14.  However, rseidues 9 - 54 in this protein match residues 9 - 54 in TC# 1.E.2.1.1 with 35% identity and 46% similarity with no gaps.

Bacteria
Cyanobacteria
Putative holin of Cyanothece sp. PCC 7425
1.E.2.3.2









Uncharacterized protein of 71 aas and 1 or 2 TMSs

Bacteria
Terrabacteria group
UP of Nostoc linckia
1.E.2.3.3









Uncharacterized protein of 83 aas and 1 TMS.

Bacteria
Terrabacteria group
UP of Oculatella sp. FACHB-28
1.E.2.3.4









Uncharacterized protein of 72 aas and 1 or 2 TMSs.

Bacteria
Terrabacteria group
UP of Calothrix brevissima
1.E.2.3.5









Uncharacterized protein of 61 aas and 1 or 2 TMSs.

Bacteria
Terrabacteria group
UP of Leptolyngbya sp. FACHB-321
1.E.2.3.6









Uncharacterized protein of 68 aas and  1 or 2 TMSs.

Bacteria
FCB group
UP of Flavobacterium sp. CLA17
1.E.2.3.7









Uncharacterized protein of 64 aas and 1 TMS

Bacteria
Terrabacteria group
UP of Desertifilum sp. SIO1I2
1.E.2.3.8









Uncharacterized protein of 71 aas and 1 or 2 TMSs.

Bacteria
Terrabacteria group
UP of Trichocoleus sp. FACHB-591
1.E.2.4.1









Putative holin of 93 aas and 3 TMSs (Zampara et al. 2020).

Viruses
Duplodnaviria
Holin of Campylobacter phage F375
1.E.2.4.2









Uncharacterized protein of 101 aas and 3 TMSs in a 1 + 2 TMS arrangement.

Bacteria
Proteobacteria
UP of Campylobacter sp. LR286c
1.E.2.4.3









Phage holin family protein of 111 aas and 3 TMSs in a 1 + 2 TMS arrangement.

Bacteria
Proteobacteria
Holin of Helicobacter japonicus
1.E.2.4.4









Uncharacterized protein of 113 aas and 3 TMSs in a 1 + 2 TMS arrangement.

Bacteria
Proteobacteria
UP of Campylobacter troglodytis