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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
1.E.2.1.1	Lysis protein S of phage lambda, holin S105. The lambda-holin protein can mediate a caspase-independent non-apoptotic mode of cell death (Agu et al. 2007). Topological class I with three TMSs. The N-terminus is outside and the C-terminus is inside (Graschopf and Bläsi 1999; Gründling et al. 2000). Nearly identical to the holin of Shigella phage Sf6 (Dover et al. 2016). It lambda protein has a three-helix topology with an unstructured C-terminal domain, as well as at least one interface on TMS1 which is exposed to the lumen of the hole, and a highly constrained steric environment suggestive of a tight helical packing interface at TMS2 (Morris et al. 2023).	Viruses	Heunggongvirae, Uroviricota	Lysis protein S (105 aas; spP03705)
1.E.2.1.2	Lysis protein 13, gp65 of enterobacterial phage P22.	Viruses	Heunggongvirae, Uroviricota	Lysis protein 13 (108 aas; spP09962)
1.E.2.1.3	Hypothetical lysis protein	Bacteria	Pseudomonadota	Hypothetical lysis protein (118 aas; spP44188)
1.E.2.1.4	Hol-1 of lysogenic Xenorhabdus nematophila (Brillard et al., 2003)	Bacteria	Pseudomonadota	Hol-1 of lysogenic Xenorhabdus nematophila (CAB58444)
1.E.2.1.5	Putative holin	Bacteria	Pseudomonadota	Putative holin of Pseudomonas syringae
1.E.2.1.6	Putative holin	Bacteria	Pseudomonadota	Putative holin of Klebsiella oxytoca
1.E.2.1.7	Putative holin	Bacteria	Pseudomonadota	Putative holin of Pantoea sp.
1.E.2.1.8	Putative holin	Bacteria	Pseudomonadota	Putative holin of Actinobacillus succinogenes
1.E.2.1.9	Putative phage-like holin of 112 aas and 3 TMSs	Bacteria	Pseudomonadota	putative holin of Hamiltonella defensa subsp. Acyrthosiphon pisum
1.E.2.1.10	Holin of 108 aas; the gene is in a prophage genome adjacent to genes encouding a lysozyme inhibitor and a lytic protein.	Bacteria	Pseudomonadota	Holin of E. coli
1.E.2.1.11	Holin (N-terminal 100 aas) fused to a D-alanyl-D-alanine carboxypeptidase (C-terminal 138 aas). The protein is 238 aas in length with 3 N-terminal TMSs.	Bacteria	Pseudomonadota	Fusion holin of Serratia odorifera
1.E.2.1.12	Putative holin of 96 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of Acinetobacter proteolyticus
1.E.2.1.13	Holin, lambda family, of 108 aas and 3 TMSs, ChiW (Hamilton et al. 2014). It is involved (possibly indirectly) in chitinase secretion (Costa et al. 2019).	Bacteria	Pseudomonadota	Holin of Serratia marcescens
1.E.2.1.14	Holin of 110 aas and 3 TMSs (Czajkowski 2019).	Bacteria	Pseudomonadota	Holin of Pectobacterium zantedeschiae
1.E.2.1.15	Holin of 110 aas with 3 TMSs.	Bacteria	Pseudomonadati, Pseudomonadota	Holin of Enterobacter cloacae
1.E.2.2.1	Helicobacter phage 1961P holin_3 superfamily protein	Viruses	Heunggongvirae, Uroviricota	Helicobacter phage 1961P holin
1.E.2.2.2	Putative holin	Bacteria	Campylobacterota	Putative holin of Campylobacter concisus
1.E.2.2.3	Putative holin	Bacteria	Campylobacterota	Putative holin of Campylobacter jejuni
1.E.2.2.4	Putative holin	Bacteria	Campylobacterota	Putative holin of Arcobacter butzleri
1.E.2.3.1	Phage-holin-3 superfamily (CDD) member of 72 aas and possibly 1-2 TMSs. Therre were no obvious homologues in the NCBI database as of 3/3/14. However, rseidues 9 - 54 in this protein match residues 9 - 54 in TC# 1.E.2.1.1 with 35% identity and 46% similarity with no gaps.	Bacteria	Cyanobacteriota	Putative holin of Cyanothece sp. PCC 7425
1.E.2.3.2	Uncharacterized protein of 71 aas and 1 or 2 TMSs	Bacteria	Cyanobacteriota	UP of Nostoc linckia
1.E.2.3.3	Uncharacterized protein of 83 aas and 1 TMS.	Bacteria	Cyanobacteriota	UP of Oculatella sp. FACHB-28
1.E.2.3.4	Uncharacterized protein of 72 aas and 1 or 2 TMSs.	Bacteria	Cyanobacteriota	UP of Calothrix brevissima
1.E.2.3.5	Uncharacterized protein of 61 aas and 1 or 2 TMSs.	Bacteria	Cyanobacteriota	UP of Leptolyngbya sp. FACHB-321
1.E.2.3.6	Uncharacterized protein of 68 aas and 1 or 2 TMSs.	Bacteria	Bacteroidota	UP of Flavobacterium sp. CLA17
1.E.2.3.7	Uncharacterized protein of 64 aas and 1 TMS	Bacteria	Cyanobacteriota	UP of Desertifilum sp. SIO1I2
1.E.2.3.8	Uncharacterized protein of 71 aas and 1 or 2 TMSs.	Bacteria	Cyanobacteriota	UP of Trichocoleus sp. FACHB-591
1.E.2.4.1	Putative holin of 93 aas and 3 TMSs (Zampara et al. 2020).	Viruses	Heunggongvirae, Uroviricota	Holin of Campylobacter phage F375
1.E.2.4.2	Uncharacterized protein of 101 aas and 3 TMSs in a 1 + 2 TMS arrangement.	Bacteria	Campylobacterota	UP of Campylobacter sp. LR286c
1.E.2.4.3	Phage holin family protein of 111 aas and 3 TMSs in a 1 + 2 TMS arrangement.	Bacteria	Campylobacterota	Holin of Helicobacter japonicus
1.E.2.4.4	Uncharacterized protein of 113 aas and 3 TMSs in a 1 + 2 TMS arrangement.	Bacteria	Campylobacterota	UP of Campylobacter troglodytis