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1.F.3.  The EH Domain-containing Protein 1 (ETMP1) Family 

ETMP1 is an ATP- and membrane-binding protein that controls membrane reorganization and tubulation upon ATP hydrolysis. In vitro, it causes vesiculation of endocytic membranes (Cai et al. 2013). It acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (Rahajeng et al. 2010). Lipid and ion transport, mitosome fission, and quality control are potential processes that are mediated by the ETMP1-EHD1-tethered mitosome-endosome contact site in E. histolytica (Santos et al. 2022).


References associated with 1.F.3 family:

Cai, B., S.S.P. Giridharan, J. Zhang, S. Saxena, K. Bahl, J.A. Schmidt, P.L. Sorgen, W. Guo, N. Naslavsky, and S. Caplan. (2013). Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. J. Biol. Chem. 288: 30172-30180. 24019528
Rahajeng, J., S.S. Giridharan, N. Naslavsky, and S. Caplan. (2010). Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J. Biol. Chem. 285: 31918-31922. 20801876
Santos, H.J., Y. Hanadate, K. Imai, H. Watanabe, and T. Nozaki. (2022). Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact. mBio 13: e0384921. 35404118
Zhang, Y., X. Yang, Y. Liu, L. Ge, J. Wang, X. Sun, B. Wu, and J. Wang. (2022). Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep 12: 12752. 35882892