TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.G.20.1.1









Envelope poly-glycoprotein of 1135 aas and 3 - 5 TMSs, Gc-GP.  Glycoprotein N (Hanta G!; N-terminal domain) and Glycoprotein C (Hanta G2; C-terminal domain) interact with each other after cleavage of the full length protein, present on the surface of the virion. They attach the virion to host cell receptors to induce virion internalization predominantly through clathrin-dependent endocytosis. Gc-GP also promotes fusion of the viral membrane with the host endosomal membrane after endocytosis of the virion (Jin et al. 2002).

Viruses
Bunyaviridae
Gc-GP of Hantaan virus (Korean hemorrhagic fever virus)
1.G.20.1.2









Polyprotein of 1432 aas and 5 - 7 TMSs.

Viruses
Bunyaviridae
Polyprotein of I612045 virus
1.G.20.1.3









M polyprotein, Gn-Gc-NSm, of 1403 aas and 5 - 7 TMSs.

Viruses
Bunyaviridae
Gn-Gc-NSm of Shamonda virus
1.G.20.1.4









The envelopment polyprotein, GP, of 1441 aas and 8 TMSs in a 1 (N-terminal) + 2 +4 + 1 (C-terminal) TMS arrangement. The precursor protein is processed to the glycoprotein (C-terminal) and glycoprotein (N-terminal) which interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (Plassmeyer et al. 2005; Pekosz et al. 1995; Hulswit et al. 2021).

Viruses
Riboviria
GP of Bunyavirus La Crosse
1.G.20.2.1









Envelope glycoprotein of 1684 aas and 5 - 8 TMSs, Env-GP, including Gn and Gc (Xiao et al. 2011).  Blocking transport out of multivesicular bodies still allowed virus entry while preventing vesicular acidification, required for membrane fusion, trapping virions in the MVBs (Shtanko et al. 2014).  Entry is dependent on the CCHFV envelope GP (Suda et al. 2016).

Viruses
Bunyaviridae
Env-GP of Crimean-Congo hemorrhagic fever virus (CCHFV)
1.G.20.2.2









GPC glycoprotein of 1296 aas and 3 - 4 TMSs.  May function in evasion or tolerance by the virus to the host immune response. 

Viruses
Bunyaviridae
GPC of the Erve virus
1.G.20.2.3









M-protein, Gn-Gc-NSm, of 1549 aas and 5 - 7 TMSs.

Viruses
Bunyaviridae
Gn-Gc-NSm of Simbu virus