TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.G.3.1.1









Tick-borne encephalitis virus (TBEV) (Class II) polyprotein of 3414 aas.  Residues 281 - 776 include the envelop protein that includes the viral fusion protein (Zhang et al. 2017).

Viruses
Flaviviridae
Tick-borne encephalitis virus polyprotein (P14336)
1.G.3.1.2









Polyprotein (3391aas) (includes the membrane fusion protein, envelope protein E (495aas; 38% identical to residues 282-774 in 1.G.3.1.1) (Liao et al., 2010)).  The fusion peptides are residues 98 - 113 in V7SFC4 and residues 378 - 393 in P14340 (Apellániz et al. 2014).

Viruses
Flaviviridae
Polyprotein of Dengue virus (P14340)
Envelope protein E (B7SFC4)
1.G.3.1.3









Polyprotein of 3432 aas of the Flavi-glycoprotein family.  The type II fusion peptide is residues 392 - 407 (Apellániz et al. 2014).

Viruses
Flaviviridae
Polyprotein of Japanese encephalitis virus
1.G.3.1.4









Non-structural protein 2B of 131 aas and 2 TMSs.

Viruses
Flaviviridae
NS2B of Usutu virus
1.G.3.1.5









NS2B of 131 aas and 2 TMSs.

Viruses
Flaviviridae
NS2B of Murray Valley encephalitis virus
1.G.3.1.6









NS2A viroporin of 218 aas and 4 - 8 TMSs (Shrivastava et al. 2017).

Viruses
Flaviviridae
NS2A of Dengue Virus
1.G.3.1.7









Polyprotein of 3433 aas and about 20 - 24 TMSs.  It includes the N2Sa protein which has been shown to be a viroporin (Leung et al. 2008).

Viruses
Flaviviridae
N2Sa of Kunjin Virus
1.G.3.1.8









Non-structural protein, NSP 2B, of 122 aas and 2 TMSs. It forms a viroporin (Shrivastava et al. 2020).

Viruses
Flaviviridae
NSP2B of Dengue virus
1.G.3.1.9









Zika viroporin, ZikV-M (the M protein) of 75 aas and 1 C-terminal TMS. Flaviviruses contain several important human pathogens. Among these, the Zika virus is an emerging etiological agent. One of its structural proteins, prM, plays an essential role in viral maturation and assembly, making it an attractive drug and vaccine development target. Tomar et al. 2022 have characterized ZikV-M as a potential viroporin candidate using three different bacterium-based assays which were used to identify potential ZikV-M blockers. Mutational analyses of conserved amino acids in the transmembrane domain of other flaviviruses, including West Nile and Dengue viruses, were performed to study their role in ion channel activity. Thus, ZikV-M is a potential ion channel that can be used as a drug target for high throughput screening and drug repurposing (Tomar et al. 2022). P2X7R is expressed in cancer and immune system cell surfaces. ATP plays a key role in numerous metabolic processes due to its abundance in the tumour microenvironment. P2X7R plays an important role in cancer by interacting with ATP. The unusual property of P2X7R is that stimulation with low doses of ATP causes the opening of a permeable channel for sodium, potassium, and calcium ions, whereas sustained stimulation with high doses of ATP favours the formation of a non-selective pore. The latter effect induces a change in intracellular homeostasis that leads to cell death.

Viruses
Riboviria
ZikV-M viroporin of Zika Virus