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1.G.9.1.1
HERV-W_7q21.2 provirus ancestral Env polyprotein (ENV-W; gPr73; enverin; syncytin-1, HERV-7q envelope protein) (Blond et al., 1999; Mi et al., 2000).  This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. It may induce fusion through binding of SLC1A4 and SLC1A5 (Blond et al. 2000; Lavillette et al. 2002; Sugimoto et al. 2013. Syncytin-1 interacts with the ASCT2 receptor (Lavillette et al. 2002; Sugimoto et al. 2013. Syncytin-1 interacts with the ASCT2 receptor (Štafl et al. 2021).  

Accession Number:Q9UQF0
Protein Name:HERV-W_7q21.2 provirus ancestral Env polyprotein
Length:538
Molecular Weight:59866.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Virion1
Substrate

Cross database links:

Entrez Gene ID: 30816   
Pfam: PF00429   
KEGG: hsa:30816   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0019012 C:virion
GO:0006949 P:syncytium formation

References (19)

[1] “Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family.”  Blond J.-L.et.al.   9882319
[2] “Syncytin is captive retroviral envelope protein involved in human placental morphogenesis.”  Sha M.et.al.   10693809
[3] “Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family.”  Voisset C.et.al.   10826480
[4] “The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology.”  Mallet F.et.al.   14757826
[5] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The HERV-W/7q family in the human genome. Potential for protein expression and gene regulation.”  Alliel P.M.et.al.   11990458
[8] “Endogenous retroviruses and multiple sclerosis. II. HERV-7q.”  Alliel P.M.et.al.   9835022
[9] “An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.”  Blond J.-L.et.al.   10708449
[10] “Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope.”  An D.S.et.al.   11238877
[11] “Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation.”  Perron H.et.al.   11531410
[12] “The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.”  Lavillette D.et.al.   12050356
[13] “Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.”  Blaise S.et.al.   14557543
[14] “The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus.”  Ponferrada V.G.et.al.   12664292
[15] “Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.”  de Parseval N.et.al.   12970426
[16] “Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta.”  Smallwood A.et.al.   12620933
[17] “Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation.”  Bonnaud B.et.al.   15254254
[18] “Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.”  Antony J.M.et.al.   15452578
[19] “Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope.”  Cheynet V.et.al.   15827173
Structure:
5HA6   6RX1     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MALPYHIFLF TVLLPSFTLT APPPCRCMTS SSPYQEFLWR MQRPGNIDAP SYRSLSKGTP 
61:	TFTAHTHMPR NCYHSATLCM HANTHYWTGK MINPSCPGGL GVTVCWTYFT QTGMSDGGGV 
121:	QDQAREKHVK EVISQLTRVH GTSSPYKGLD LSKLHETLRT HTRLVSLFNT TLTGLHEVSA 
181:	QNPTNCWICL PLNFRPYVSI PVPEQWNNFS TEINTTSVLV GPLVSNLEIT HTSNLTCVKF 
241:	SNTTYTTNSQ CIRWVTPPTQ IVCLPSGIFF VCGTSAYRCL NGSSESMCFL SFLVPPMTIY 
301:	TEQDLYSYVI SKPRNKRVPI LPFVIGAGVL GALGTGIGGI TTSTQFYYKL SQELNGDMER 
361:	VADSLVTLQD QLNSLAAVVL QNRRALDLLT AERGGTCLFL GEECCYYVNQ SGIVTEKVKE 
421:	IRDRIQRRAE ELRNTGPWGL LSQWMPWILP FLGPLAAIIL LLLFGPCIFN LLVNFVSSRI 
481:	EAVKLQMEPK MQSKTKIYRR PLDRPASPRS DVNDIKGTPP EEISAAQPLL RPNSAGSS