1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family
Claudins are integral transmembrane components of tight junctions (TJs), forming trans-epithelial barriers in many organs, such as the nervous system, lungs and epidermis. In Drosophila, three claudins have been identified which are required for forming the TJ analogous structures - the septate junctions (SJs). The lack of claudins results in disruption of the integrity of the SJs, leading to the breakdown of the trans-epithelial barrier and disturbed epithelial morphogenesis. These homologues are involved in transport and membrane organization. They associate with over 100 proteins in the Drosophila proteome (Jaspers et al., 2012).