TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.N.4.1.1









EFF-1A of 658 aas and 2 TMSs, N- and C-terminal.  Required for normal cell fusion. The EFF-1A endodomain is required for normal rates of EFF-1-dependent epidermal cell fusions (Shinn-Thomas et al. 2016).

Eukaryota
Metazoa, Nematoda
EFF1A of Caenorhabditis elegans
1.N.4.1.2









EFF-1B of 596 aas and 2 TMSs, N- and C-terminal (Kontani and Rothman 2005).

Eukaryota
Metazoa, Nematoda
EFF-1B of Caenorhabditis elegans
1.N.4.1.3









Myoblast syncytium formation protein generated by plasma membrane fusion of 852 aas and 4 - 5 TMSs.  The roles of the major signaling pathways in mammalian myoblast fusion have been reviewed (Hindi et al. 2013).

 

Eukaryota
Metazoa, Chordata
FFF protein of Branchiostoma floridae (Florida lancelet) (Amphioxus)
1.N.4.1.4









Cell fusion protein, AFF-1 of 589 aas and 2 TMSs, one N-terminial and one C-terminal (Soulavie and Sundaram 2016).  Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Procko et al. 2011).

Eukaryota
Metazoa, Nematoda
AFF-1 of Caenorhabditis elegans
1.N.4.1.5









Uncharacterized fusogen protein of 567 aas and 2 TMSs.

Eukaryota
Metazoa, Nematoda
Putative fusogen of Trichinella spiralis (Trichina worm)