TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.N.5.1.1









Atlastin 1, ALT1, of 558 aas and 2 closely packed C-terminal TMSs (McNew et al. 2013).

Eukaryota
Metazoa
Atlastin 1 of Homo sapiens
1.N.5.1.2









Atlastin of 541 aas and 2 TMSs near the C-terminus of the protein.  It is a GTPase, tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes (Orso et al. 2009). It functions in endoplasmic reticulum tubular network biogenesis and may also regulate microtubule polymerization and Golgi biogenesis. It is required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions (Lee et al. 2009).

Eukaryota
Metazoa
Alastin of Drosophila melanogaster (Fruit fly)
1.N.5.1.3









Atlastin of 968 aas and 1 or 2 C-terminal TMSs.

Eukaryota
Blastocystis
Atlastine of Blastocystis sp.
1.N.5.1.4









Atlastin-1-like isoform X2of 270 aas and 2 TMSs.

Eukaryota
Metazoa
ATL1 of Varroa jacobsoni
1.N.5.1.5









Atlastin homologue of 602 aas and 1 putative N-terminal TMS and 3 C-terminal TMSs.

Eukaryota
Viridiplantae
Putative Atlastin of Arabidopsis thaliana
1.N.5.1.6









Sey1 of 776 aas and 2 C-terminal TMSs, possibly with 1 or 2 N-terminal TMS(s).  It cooperates with the reticulon proteins RTN1 and RTN2 (see TC family 8.A.102) and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER membrane fusion and reorganization (Hu et al. 2009; Hu and Rapoport 2016). Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion (Lee et al. 2019).

 

Eukaryota
Fungi
Sey1 of Saccharomyces cerevisiae (Baker's yeast)