1.O.5. The Amphiphilic Conjugated Polymer Nanoparticle-inducing pore (CPN-P) Family
Biophysicochemical interactions at the nano-bio interface are important for basic cell biology and applications in nanomedicine and nanobiosensors. The extracellular surface potential and topographical changes of live cell membranes interacting with polymeric nanomaterials using a scanning ion conductance microscopy-based potential imaging technique have been characterized (Chen et al. 2018). Two structurally similar amphiphilic conjugated polymer nanoparticles (CPNs) containing different functional groups (i.e., primary amines versus guanidine) have been used to study incubation time and functional group-dependent extracellular surface potential and topographic changes (Chen et al. 2018). Transmembrane pores, which induce significant changes in potential, only appeared transiently in the live cell membranes during the initial interactions. The cells were able to self-repair the damaged membrane and become resilient to prolonged CPN exposure.