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1.W.5.  The (Lambda) Phage Portal Protein 5 (PPP5) Family

The Escherichia phage lambda (Bacteriophage lambda) portal protein forms the portal vertex of the capsid (Kochan and Murialdo 1983). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (Kochan et al. 1984). It binds to the terminase subunits to form the packaging machine (Yeo and Feiss 1995).

This family belongs to the: Phage Portal Protein (PPP) Superfamily.

References associated with 1.W.5 family:

Kochan, J. and H. Murialdo. (1983). Early intermediates in bacteriophage lambda prohead assembly. II. Identification of biologically active intermediates. Virology 131: 100-115. 6228056
Kochan, J., J.L. Carrascosa, and H. Murialdo. (1984). Bacteriophage lambda preconnectors. Purification and structure. J. Mol. Biol. 174: 433-447. 6232391
Yeo, A. and M. Feiss. (1995). Specific interaction of terminase, the DNA packaging enzyme of bacteriophage lambda, with the portal protein of the prohead. J. Mol. Biol. 245: 141-150. 7799432