| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.X.1.1.1 | The Intraflagellar transporter (IFT) multiprotein complex. WD repeat-containing protein 35 of 1181 aas and possibly as many as 7 or 8 TMSs. It is a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). It is thus involved in ciliogenesis and ciliary protein trafficking (Takahara et al. 2018) (see the family description). Many other proteins play a role as constituents of the IFT complex, and some of these (but not all of them) are listed under this TC# (Lechtreck 2022). | Eukaryota |
Metazoa, Chordata | IFT complex of Homo sapiens WD repeat protein 35 of 1181 aas, Q9P2L0 IFT dynein (part of the motor) of 1066 aas, Q8WVS4 IFT kinesin-2, IFT88, 824 aas, Q13099 IFT25/27 adaptor, 186 aas, (adaptor for cargo BBSome), Q9BW83 IFT56, 554 aas (adaptor for cargo IDA3), A0AVF1 IFT46, 304 aas (adaptor for cargo ODA16), Q9NQC8 IFT81, 676 aas (adaptor for cargo alpha), Q8WYA0 IFT74, 600 aas (adaptor for cargo beta), Q96LB3 IFT122, 1241 aas (adaptor for cargo TULP3), Q9HBG6 |
|
1.X.1.1.2 | The sensory ciliary function underlying hearing in the adult fly requires an active maintenance program which involves DmIFT88 and at least two of its signalling transmembrane cargoes, DmGucy2d and Inactive (Werner et al. 2024). | Eukaryota |
Metazoa, Arthropoda | Complex of three proteins of Drosophila melanogaster |
|
1.X.1.1.3 | Intraflagellar transport protein complex of several proteins, IFT52, of 426 aas and possibly 1 TMS at about residue 180; IFT57, of 429 aas; IFT43, of 208 aas; IFT46, of 301 aas, and IFT20, of 132 aas (Reddy Palicharla and Mukhopadhyay 2024). See 1.X.1.1.1 for description. | Eukaryota |
Metazoa, Chordata | IFT complex of Mus musculus |