2.A.1.1.1
Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977; Henderson et al. 1977; Hernández-Montalvo et al., 2001). Relative substrate affinities of wild-type and mutant forms of the E. coli sugar transporter GalP have been determined by solid-state NMR (Patching et al., 2008). GalP may exist as a trimer with each subunit having a sugar transporting channel (Zheng et al. 2010).
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| Accession Number: | P0AEP1 |
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| Protein Name: | Galactose-proton symporter |
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| Length: | 464 |
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| Molecular Weight: | 50983.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
aldehydo-D-xylose, galactose, D-fucopyranose, 2-deoxy-D-galactopyranose, D-galactopyranose, 2-deoxy-D-glucopyranose |
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1: MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT SHTQEWVVSS
61: MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA AAPNVEVLIL SRVLLGLAVG
121: VASYTAPLYL SEIAPEKIRG SMISMYQLMI TIGILGAYLS DTAFSYTGAW RWMLGVIIIP
181: AILLLIGVFF LPDSPRWFAA KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA
241: LFKENSNFRR AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN
301: VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF AIAMLLMFIV
361: GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI VGATFLTMLN TLGNANTFWV
421: YAALNVLFIL LTLWLVPETK HVSLEHIERN LMKGRKLREI GAHD