2.A.1.1.78
The glucose transporter, LmGT3 (homologous to LmGT2 (1.A.1.1.75)). Two
threonine residues located in the hydrophilic loops connecting TMSs 3
& 4 and 7 & 8 of GT3 prevent transport of D-ribose. Changing
these two residues to alanine (as in GT2) allows transport of ribose.
Thus, loops 3-4 and 7-8 partially determine substrate specificity (Naula et al., 2010).
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| Accession Number: | O61060 |
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| Protein Name: | Glucose transporter |
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| Length: | 566 |
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| Molecular Weight: | 61250.00 |
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| Species: | Leishmania mexicana [5665] |
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| Number of TMSs: | 12 |
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| Substrate |
glucose |
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| Pfam: |
PF00083
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[1] “Differential regulation of multiple glucose transporter genes in Leishmania mexicana.” Burchmore R.J. et.al. 9786920
[2] “A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.” Naula C.M. et.al. 20601430
[3] “Differential regulation of multiple glucose transporter genes in Leishmania mexicana.” Burchmore R.J. et.al. 9786920
[4] “A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.” Naula C.M. et.al. 20601430
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1: MSDKLEANVQ SSNWLSEEPA RPDANKLGDE DDSPPFFSMS NVRVAMVQAI GGCLNGYSIG
61: FVGVYSTLFG YSTNCANFRS ERGCTTAPNA DCQWFANATG TSYCGWPEIT CRRTYTYSSV
121: AEMPGAIAQC EADSRCRWSY SAEECQNPSG YSSSESGIFA GSMIAGCLIG SVFAGPLAST
181: IGARLSFLLV GLVGVVSSVM YHVSTGENEF WVLVVGRFVI GLFVGVIGVA CPVYTDQNAH
241: PKWKRTIGVM FQVFTTLGIF IAAAVGLALG QSTYFDRNKD QMVMARMQGL CAFSTLFSLL
301: TILLGIVMSE SRAKFGGDDE EGGIELDPNE YSYVEMVPRL LMGAVMAGTL QLTGINAVMN
361: YAPTIMGSLG LAPLVGNFVV MLWNFVTTLA SIPLSYVFTM RQLFLFGSLF TSSMCLFMCG
421: IPVYPGVSKK TEVKNGVAIT GILLFILGFE VCVGPCYYVL TQDMFPLSFR PRGASLTQVT
481: QFLFNLVINV CYPIATEHIS GGLSGNQDKG QAVAFIFFGC VGMICFIIQV FFLHPWDEKR
541: DGKKRPATPA GGKRELSGEF VGKKEV