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2.A.1.1.99 Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a K_m of 11 mM (Kanamori et al. 2010). Tret1 orthologs of other insects examined have differing Km values (Apis mellifera, 9 mM; Anopheles gambiae, 46 mM, and Bombyx mori, 72 mM).
Accession Number:	A1Z8N1
Protein Name:	Facilitated trehalose transporter Tret1-1
Length:	857
Molecular Weight:	95188.00
Species:	Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	alpha,alpha-trehalose

Entrez Gene ID:	36248
Pfam:	PF00083
KEGG:	dme:Dmel_CG3003
Gene Ontology GO:0016021 C:integral to membrane GO:0044459 C:plasma membrane part GO:0015574 F:trehalose transmembrane transporter activity
References (4) [1] “The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues.” Kanamori Y.et.al. 20035867 [2] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132 [3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [4] “Phosphoproteome analysis of Drosophila melanogaster embryos.” Zhai B.et.al. 18327897

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSGRDNRGAG GGGGGHQPLS NAMGKLKEKL TRVGDELGYH RVESNLSTSN TATSLDTILP 
61:	EDPFLFPQVS PQRHPQNTVR TQRLLEDEPP LSFRPLLEDD DINEPPTQQQ QRTPLRASGS 
121:	LELTPLPPPP TSLEIREHRD RQQRGAQGDE LQRSKQSLKG SRVSFERRDT GNSNTNSNKA 
181:	AESSDEDSFE EKRTGFQQQK ATSVDHKGIL KDLKHILAND NRRQFQAKKH VSLDVKGTRF 
241:	LQDLLKESSS EEEFHKTRRE FQGRKHQSLD PRVTFKLDKV LQGSSTDSDE EGEDAEHKRL 
301:	IHRPKDITKP VIIDLKDLES ESDEDFLTSR QHFQQQRSIS TDSRKSRRLY EMDEMDNKRG 
361:	ENIRHAVPFV RQITEDGKPK LEVYRPTTNP IYIWTQVLAA LSVSLGSLVV GFVSAYTSPA 
421:	LVSMTDRNIT SFEVTQDAGS WVGGIMPLAG LAGGIAGGPL IEYLGRRNTI LATAVPFIVS 
481:	SLLIACAVNV AMVLCGRFLA GFCVGIASLS LPVYLGETVQ PEVRGTLGLL PTAFGNIGIL 
541:	LCFVAGSFMN WSMLAFLGAA LPVPFLILMF LIPETPRWFV GRGLEERARK ALKWLRGKEA 
601:	DVEPELKGLM RSQADADRQA SRNTMLELLK LNNLKPLSIS LGLMFFQQFS GINAVIFYTV 
661:	QIFKDAGSTI DGNLCTIIVG IVNFLATFIG IVLIDRAGRK ILLYVSDIAM VLTLFVLGGF 
721:	FYCKTYGPDV SHLGWLPLTC FVIYILGFSL GFGPIPWLMM GEILPAKIRG SAASVATAFN 
781:	WFCTFVVTKT FQDLTVAMGA HGAFWLFGAI CFVGLFFVII YVPETQGKTL EDIERKMMGR 
841:	VRRMSSVANI KPLSFNM

2.A.1.1.99
Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a K_m of 11 mM (Kanamori et al. 2010). Tret1 orthologs of other insects examined have differing Km values (Apis mellifera, 9 mM; Anopheles gambiae, 46 mM, and Bombyx mori, 72 mM).

Cross database links:

Gene Ontology

References (4)

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2.A.1.1.99Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a Km of 11 mM (Kanamori et al. 2010). Tret1 orthologs of other insects examined have differing Km values (Apis mellifera, 9 mM; Anopheles gambiae, 46 mM, and Bombyx mori, 72 mM).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.1.1.99
Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a K_m of 11 mM (Kanamori et al. 2010). Tret1 orthologs of other insects examined have differing Km values (Apis mellifera, 9 mM; Anopheles gambiae, 46 mM, and Bombyx mori, 72 mM).