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2.A.1.10.1 Nucleoside porter, NupG. Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported (Patching et al. 2005). ADP-glucose is also a substrate of this system (Almagro et al. 2018 Almagro et al. 2018).
Accession Number:	P0AFF4
Protein Name:	Nucleoside permease NupG aka B2964
Length:	418
Molecular Weight:	46389.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	cytidine, adenosine, guanosine, thymidine, inosine

RefSeq:	AP_003521.1 NP_417439.4
Entrez Gene ID:	946282
BioCyc:	EcoCyc:NUPG-MONOMER ECOL168927:B2964-MONOMER
KEGG:	ecj:JW2932 eco:b2964
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005337 F:nucleoside transmembrane transporter activity GO:0015858 P:nucleoside transport
References (4) [1] “Studies on the sequence and structure of the Escherichia coli K-12 nupG gene, encoding a nucleoside-transport system.” Westh Hansen S.E.et.al. 3311747 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MNLKLQLKIL SFLQFCLWGS WLTTLGSYMF VTLKFDGASI GAVYSSLGIA AVFMPALLGI 
61:	VADKWLSAKW VYAICHTIGA ITLFMAAQVT TPEAMFLVIL INSFAYMPTL GLINTISYYR 
121:	LQNAGMDIVT DFPPIRIWGT IGFIMAMWVV SLSGFELSHM QLYIGAALSA ILVLFTLTLP 
181:	HIPVAKQQAN QSWTTLLGLD AFALFKNKRM AIFFIFSMLL GAELQITNMF GNTFLHSFDK 
241:	DPMFASSFIV QHASIIMSIS QISETLFILT IPFFLSRYGI KNVMMISIVA WILRFALFAY 
301:	GDPTPFGTVL LVLSMIVYGC AFDFFNISGS VFVEKEVSPA IRASAQGMFL MMTNGFGCIL 
361:	GGIVSGKVVE MYTQNGITDW QTVWLIFAGY SVVLAFAFMA MFKYKHVRVP TGTQTVSH

2.A.1.10.1
Nucleoside porter, NupG. Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported (Patching et al. 2005). ADP-glucose is also a substrate of this system (Almagro et al. 2018 Almagro et al. 2018).

Cross database links:

Gene Ontology

References (4)

External Searches:

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2.A.1.10.1Nucleoside porter, NupG. Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported (Patching et al. 2005). ADP-glucose is also a substrate of this system (Almagro et al. 2018Almagro et al. 2018).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.1.10.1
Nucleoside porter, NupG. Guanosine, inosine, cytidine and thymidine but not uridine, adenosine and xanthosine are transported (Patching et al. 2005). ADP-glucose is also a substrate of this system (Almagro et al. 2018 Almagro et al. 2018).