2.A.1.10.2
Xanthosine porter, XapB. Xanthosine, inosine, adenosine, cytidine and thymidine but not guanosine and uridine are transported (Seeger et al. 1995). The Km for Xanthosine is 136 μM (Nørholm and Dandanell 2001). The transporter is encoded within an operon with xanthosine phosphorylase which is inactive in S. enterica but can be mutated to the active form (Hansen et al. 2006).
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| Accession Number: | P45562 |
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| Protein Name: | Xanthosine permease |
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| Length: | 418 |
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| Molecular Weight: | 46140.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cytidine, adenosine, thymidine, inosine, xanthosine |
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1: MSIAMRLKVM SFLQYFIWGS WLVTLGSYMI NTLHFTGANV GMVYSSKGIA AIIMPGIMGI
61: IADKWLRAER AYMLCHLVCA GVLFYAASVT DPDMMFWVML VNAMAFMPTI ALSNSVSYSC
121: LAQAGLDPVT AFPPIRVFGT VGFIVAMWAV SLLHLELSSL QLYIASGASL LLSAYALTLP
181: KIPVAEKKAT TSLASKLGLD AFVLFKNPRM AIFFLFAMML GAVLQITNVF GNPFLHDFAR
241: NPEFADSFVV KYPSILLSVS QMAEVGFILT IPFFLKRFGI KTVMLMSMVA WTLRFGFFAY
301: GDPSTTGFIL LLLSMIVYGC AFDFFNISGS VFVEQEVDSS IRASAQGLFM TMVNGVGAWV
361: GSILSGMAVD YFSVDGVKDW QTIWLVFAGY ALFLAVIFFF GFKYNHDPEK IKHRAVTH