2.A.1.11.11 PfMFSDT (PF3D7_0210300) is a drug exporter (Maurya et al. 2024). It confers resistance to antifungal agents, ketoconazole and itraconazole. The
nanomolar inhibitory effects of the drugs on the intra-erythrocytic
growth of Plasmodium falciparum highlight their antimalarial properties.
|
Accession Number: | XP_001349611.1 |
Protein Name: | XP_001349611.1 monocarboxylate transporter, putative [Plasmodium falciparum 3D7] |
Length: | 458 |
Molecular Weight: | |
Species: | Plasmodium falciparum 3D7 [36329] |
Number of TMSs: | 12 |
Substrate |
ketoconazole, botanical anti-fungal agent, itraconazole |
---|
1: MKKENTSLLS SRYRIILGGF LIHCTLGSIY CFSNISVYVI SYMKIIGCSD VKYKDSSWIY
61: VLTLLFQCFF GFFGGILNQN LGPQISVLLG GWLMCLGILL SYFTVFNFYL FLMTYGILCG
121: IGCGIAYPIP LSVAVKKHYD YKGVISGIIF IGRGLSVFII CPLQNYYINK YNYMPDYMPE
181: IENSDEKYFS NLDILNKVPY LFIYEGICFA IIQFLGSYLI ADSGDTSKDF MAYNDRNNKV
241: LYFEEKNFIN KPNGLSNSLR TLSNTSNFSF REVNNTFINR EFILIWLMIF FNWQAISYTQ
301: VFWKIFGMNY LSIDDRSLSL LGSVSSLFNI FGRIFWGLIS DFTSFKTTLI LMSLLMSFLT
361: ITLTMSGFYG IITYSIWVCL IFFCHAGTFA IFPSITAHTF GTKNFGPVFG LLFTARAFSS
421: IINAIISAVL LNNIGNIAMC AIVSLSSFVS IMLALAF