2.A.1.12.3
Jen2 of 513 aas and 12 TMSs. It is a dicarboxylic acid (succinate, malate, fumarate) uptake porter, and is subject to catabolite repression by glucose. It is induced during infection, being upregulated following the phagocytosis of C. albicans cells by neutrophils and macrophages. It may be important during early stages of virulence (Vieira et al. 2010). In the acid-tolerant yeast, Pichia kudriavzevii, it transports the above mentioned dicarboxylates as well as α-ketoglutarate (sometimes) and citrate, and possibly lactate (Xi et al. 2021).
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| Accession Number: | AOW29153.1 |
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| Protein Name: | AOW29153.1 Jen2p [Candida albicans SC5314] |
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| Length: | 514 |
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| Molecular Weight: | |
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| Species: | Candida albicans SC5314 [237561] |
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| Number of TMSs: | 9 |
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| Substrate |
fumarate(2-), citrate salt, lactate, 2-oxoglutarate(2-), malate(2-), succinate(2-) |
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1: MTAADTHSIT SADVQEHNRH IIRPPKFTWP AIRKYAITRV TSLWVGWDEL KQYSWHEVLN
61: PFEPLVEMNL HQWNFFFLGF WAWTWDALDF FVTSLNVSNI AEDLDSTVKD VSWGITLVLM
121: LRTVGALIFG AIGDTYGRKW PYIINLSCLM VIQIGTGFVT TFQQFLGLRA LFGVAMGGLF
181: GICAAEALGD APKKARGVLS GIFQEGYAFG YLLAVVFQRA IADTTEKTWR SVFWFSAGPP
241: IILIIWRFIN PETDSYQRQK ERFDQGAVQK NSKAAEFKSQ AKKALNQYWL IIVYLIFLMA
301: GFNFSSHGSQ DLYPTMLTKQ YHYGKDKSTV VNVCANLGAL AGGIVIAHLS TFIGRRTAIL
361: IGNVIAGIMI YFWAFHPMWI TAFFMQFGIQ GSWSVVPIHL SELSPPHFRS FVSGVSYQLG
421: NLVSSASSTI EATIEEQIHD YGKTMAIFIG AVLAYLMFVV FIGPENRGAE LGVERDDEYS
481: AYDSDREDRG DSDLEEGNIT QKTLEKPEVE HKE