2.A.1.12.4 Jen1 of 541 aas and 12 TMSs. Zt is a monocarboxylate (lactate) uptake porter that is upregulated following the phagocytosis of Candida albicans cells by neutrophils and macrophages. It may be important for virulence (Soares-Silva et al. 2013; Vieira et al. 2010). It may be the only lactate uptake porter and is subject to glucose catabolite repression. However, growth on lactate affects biofilm formation, morphology and
susceptibility to fluconazole, and both Jen1 and Jen2 may play a
role in these processes. Thus, the
adaptation of Candida cells to the carbon source present in the host
niches affects their pathogenicity (Alves et al. 2017; Alves et al. 2020).
|
Accession Number: | AOW28664.1 |
Protein Name: | AOW28664.1 Jen1p [Candida albicans SC5314] |
Length: | 542 |
Molecular Weight: | |
Species: | Candida albicans SC5314 [237561] |
Number of TMSs: | 11 |
Substrate |
monocarboxylic acid anion, lactate |
---|
1: MEEKARADHI SITNSNELNY DDYSNSYKNQ PELDDELFNE KPDLSLSSIS RYFATRLTTL
61: LDLPLYHTHK KWYEVINPIP GLKSMSKSDW NFYCLGFFAW ALDAMDFFCV SVAAPEIANT
121: LNISVTDVTW GVTLVLMLRS VGAVIFGIAS DYFGRKWTYI SIVTLFVVVE VGTGFVQTYQ
181: QFLGVRAIFG ILMGAMYPIA MVTALEGQPI AARSVLSGLF LPGYCFGYIM AMVWYRAFAG
241: TYKEGEGWRS LIWFSGGLSL ILIVWRLFTP ESPDYIKMKI KKEKFNQQQR LKEQEQNGGV
301: AVKEKKFWQK IDKSILVTFK TEWLIFSYLV LLYAGWNFTT HGSQDLYVTM ITKQYHVGLD
361: KKTVIIVVSN IGGIIGGIIM GQASELLGRR LTVVISIVCA GAFLYPSFFN PDRNWPAYIF
421: LNAFVFGSFS VGPAYLLELV NSTHRTLLSG VAYQLGNLVS SASATIEAKI GERFPLKDQP
481: GMFDYGKVMC IFCGAIFAYM IFIIFLGPER FHRDLQIHDT DEIEELQQDS SSNNESVKER
541: V