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2.A.1.13.15
Monocarboxylate transporter 7 (MCT 7; mTORC1) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) of 523 aas and 12 TMSs in a 6 + 6 TMS arrangement. SLC16a6, mTORC1, and autophagy regulate ketone body excretion in intestinal cells (Uebanso et al. 2023). Taurine is a substrate of this system (Higuchi 2024).

Accession Number:O15403
Protein Name:Monocarboxylate transporter 7
Length:523
Molecular Weight:57393.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate monocarboxylic acid anion

Cross database links:

Entrez Gene ID: 9120   
Pfam: PF07690   
KEGG: hsa:9120   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0008028 F:monocarboxylic acid transmembrane transporter activity
GO:0015293 F:symporter activity

References (5)

[1] “Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.”  Price N.T.et.al.   9425115
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[4] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[5] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN DLMDSFNESN 
61:	SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL VSTGMVAASF SQEVSHMYVA 
121:	IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR 
181:	YSLLFVGLLQ LNIVIFGALL RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS 
241:	GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF 
301:	GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY 
361:	IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GTHIPLLAED DVVGIEKMSS 
421:	AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ 
481:	HHHSGETKVV SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV