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2.A.1.14.13 Broad specificity brain synaptic vesicle anion:Na⁺ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities (Omote et al., 2011).
Accession Number:	Q62634
Protein Name:	BNPI
Length:	560
Molecular Weight:	61665.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cytoplasmic vesicle¹ / Multi-pass membrane protein²
Substrate	chloride, phosphate(3-), glutamate(2-)

RefSeq:	NP_446311.1
Entrez Gene ID:	116638
Pfam:	PF07690
KEGG:	rno:116638
Gene Ontology GO:0030054 C:cell junction GO:0016021 C:integral to membrane GO:0030672 C:synaptic vesicle membrane GO:0019717 C:synaptosome GO:0005315 F:inorganic phosphate transmembrane transport... GO:0015321 F:sodium-dependent phosphate transmembrane tr... GO:0015293 F:symporter activity GO:0006836 P:neurotransmitter transport GO:0006817 P:phosphate transport GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (10) [1] “Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter.” Ni B.et.al. 8202535 [2] “Developmentally-regulated expression of tissue-specific splice variant of rat vesicular glutamate transporter 1 in retina and pineal gland.” Nogami H.et.al. 16987242 [3] “Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.” Takamori S.et.al. 11001057 [4] “Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.” Bellocchio E.E.et.al. 10938000 [5] “The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons.” Herzog E.et.al. 11698619 [6] “Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).” Takamori S.et.al. 11698620 [7] “The expression of vesicular glutamate transporters defines two classes of excitatory synapse.” Fremeau R.T. Jr.et.al. 11502256 [8] “The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone.” Gras C.et.al. 18278042 [9] “Molecular anatomy of a trafficking organelle.” Takamori S.et.al. 17110340 [10] “Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging.” Mackenzie B.et.al. 18080752

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEFRQEEFRK LAGRALGRLH RLLEKRQEGA ETLELSADGR PVTTHTRDPP VVDCTCFGLP 
61:	RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVVQKAQFN WDPETVGLIH 
121:	GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG 
181:	LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV 
241:	YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 
301:	SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ 
361:	IADFLRSRHI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS 
421:	GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY 
481:	GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD ESEMEDEVEP PGAPPAPPPS 
541:	YGATHSTVQP PRPPPPVRDY

2.A.1.14.13
Broad specificity brain synaptic vesicle anion:Na⁺ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities (Omote et al., 2011).

Cross database links:

Gene Ontology

References (10)

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2.A.1.14.13Broad specificity brain synaptic vesicle anion:Na+ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities (Omote et al., 2011).

Cross database links:

Gene Ontology

References (10)

External Searches:

Analyze:

2.A.1.14.13
Broad specificity brain synaptic vesicle anion:Na⁺ symporter (transports glutamate, phosphate, chloride, etc.)(BNPI, EAT-4, VGLUT1) Chloride and ketone bodies regulate VGLUT activities (Omote et al., 2011).