2.A.1.14.15
Apical membrane renal proximal tubular voltage-driven but Na+-independent organic anion transporter, OATv1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) (Jutabha et al., 2003)
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| Accession Number: | Q7YQJ7 |
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| Protein Name: | Organic anion transporter OATv1 |
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| Length: | 467 |
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| Molecular Weight: | 52070.00 |
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| Species: | Sus scrofa (Pig) [9823] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
p-aminohippuric acid, xenobiotic, p-aminohippurate, drug |
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| RefSeq: |
NP_999509.1
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| Entrez Gene ID: |
397621
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| Pfam: |
PF07690
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| KEGG: |
ssc:397621
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[1] “Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.” Jutabha P. et.al. 12740363
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1: MLMDNQVPPK KVPKFCSVRY GIAILLLFCN VVVMSQRVCI SLTMIAMVNS TEPHGLSNIS
61: TKELQDNIKN PVYNWSPEIQ GIILSSIFYG VLISQIPAGY LSGIYSLKKM IGFALFFSSL
121: FTLLIPPVAE LGETLVIVCR IIKGLFQGVT LTAQQIIWTK WAPPLEQGRL TSLSLSGLLL
181: GPCVVMLMTG FICDSLGWPM VFYIFGAMGC VLSLLWFILY YEYPKDHPFI SIGEKEYITS
241: SLDQQDSSNS PSLPIKAMIK SPPLWVISLT NFAFFWTNSI LSMYTPMFIN FRFQINIREN
301: GLLSSLPHLF AWIFAVLAGH MADVFLSKNI LSLLTIRKLF TSLGLLLPAI FCLSLLYLSS
361: SFHATMIFLT LANATGSFTM GGLLINVLDI APRYYGFLKG VTNVIGLTGG LVSSTLTGMM
421: LSQDSESSWF KIFFLMSAIN VISQILYIIF AKAEVQDWAK ERQNTYL