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2.A.1.14.31
Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na+-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6, SLC17A6). It has 582 aas with 12 probable TMSs. It is expressed in different nerve fibre populations that selectively contact pulmonary neuroepithelial bodies (Brouns et al. 2004).

Accession Number:Q9P2U8
Protein Name:Vesicular glutamate transporter 2
Length:582
Molecular Weight:64392.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1
Substrate sodium(1+), phosphate(3-), glutamate(2-)

Cross database links:

Entrez Gene ID: 57084   
Pfam: PF07690   
KEGG: hsa:57084   

Gene Ontology

GO:0030054 C:cell junction
GO:0005769 C:early endosome
GO:0016021 C:integral to membrane
GO:0030672 C:synaptic vesicle membrane
GO:0019717 C:synaptosome
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006811 P:ion transport
GO:0001504 P:neurotransmitter uptake
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter.”  Aihara Y.et.al.   10820226
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).”  Takamori S.et.al.   11698620
[5] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC 
61:	DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 
121:	PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 
181:	IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 
241:	GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 
301:	TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 
361:	IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 
421:	GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 
481:	LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 
541:	TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS