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2.A.1.14.6 Na:P_i symporter, NPT1 or SLC17A1. (Renal chloride-dependent polyspecific anion exporter; transports organic acids such as p-aminohippurate, ureate, and acetylsalicylate (asprin)). Catalyzes ureate excretion. A mutant form shows increased risk of gout in humans.
Accession Number:	Q61983
Protein Name:	Npt1 aka SLC17A1
Length:	465
Molecular Weight:	51589.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	p-aminohippuric acid, oxaluric acid, acetylsalicylic acid, phthalate

Pfam:	PF07690
Gene Ontology GO:0016021 C:integral to membrane GO:0015114 F:phosphate transmembrane transporter activity GO:0015293 F:symporter activity GO:0006817 P:phosphate transport GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (3) [1] “Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter.” Chong S.S.et.al. 7611445 [2] “Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity.” Soumounou Y.et.al. 11704559 [3] “Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins.” Gisler S.M.et.al. 11099500

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG SPHLSNESVV 
61:	EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS GIYPMKRIIG SSLFLSSLMS 
121:	LLIPPAAQVG AALVIVCRVL QGIAQGTVST GQHEIWVKWA PPLERGRLTS MTLSGFVMGP 
181:	FIVLLVSGFI CDLLGWPMVF YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL 
241:	MQQASSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL 
301:	LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI MCLLYLSYNF 
361:	YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT ALIGMFGGLI SSTLAGLILN 
421:	QDPEYAWHKI SFLMAGINVT CLVFYFLFAK GEIQDWAKEI KTTRL

2.A.1.14.6
Na:P_i symporter, NPT1 or SLC17A1. (Renal chloride-dependent polyspecific anion exporter; transports organic acids such as p-aminohippurate, ureate, and acetylsalicylate (asprin)). Catalyzes ureate excretion. A mutant form shows increased risk of gout in humans.

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

2.A.1.14.6Na:Pi symporter, NPT1 or SLC17A1. (Renal chloride-dependent polyspecific anion exporter; transports organic acids such as p-aminohippurate, ureate, and acetylsalicylate (asprin)). Catalyzes ureate excretion. A mutant form shows increased risk of gout in humans.

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

2.A.1.14.6
Na:P_i symporter, NPT1 or SLC17A1. (Renal chloride-dependent polyspecific anion exporter; transports organic acids such as p-aminohippurate, ureate, and acetylsalicylate (asprin)). Catalyzes ureate excretion. A mutant form shows increased risk of gout in humans.