2.A.1.16.9
Siderophore iron transporter 3, Str3 of 630 aas and 14 TMSs in a 6 + 7 + 1 TMS arrangement. It transports siderophore iron and so plays a role in iron homeostasis (Pelletier et al. 2003). It also transports heme, and the peroxiredoxin, Tpx1 (Q74887; 192 aas and 0 - 2 possible TMSs), is a binding partner of Str3 (Normant et al. 2020). Under microaerobic conditions, cells deficient in heme biosynthesis and lacking the heme receptor Shu1 exhibit poor hemin-dependent growth in the absence of Tpx1, a cytoplasmic heme binding protein. Tpx1 exhibits an equilibrium constant value of 0.26 muM for hemin. The association of Tpx1 with hemin protects hemin from degradation by H2O2, and the peroxidase activity of hemin is lowered when it is bound to Tpx1 (Normant et al. 2020).
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| Accession Number: | Q92341 |
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| Protein Name: | Siderophore iron transporter 3 |
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| Length: | 630 |
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| Molecular Weight: | 70558.00 |
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| Species: | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ferroheme b |
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1: MEAKETHSIS DHEVELQDAK PEEKSENGNF VFEKAFSSDE EKGSGYNTNE TYSKMDNSLQ
61: HRGVSKIEAV RDSIYQNKRG MYLAYAFGIA ILACSWASAI QSSTTYSYQV YATASFNRTS
121: MISTLEIATA IISSVCKPIL GKFSDITSRP MTYTLVLLFY VIGFIVVASS STISAYVIGS
181: VFISIGSSGL DYLNTLVVGD LTSLKWRGFM TALLSTPYIA TVWFTGFIVQ GIIDSNWRWG
241: YGMFAIIMPA VMTPAVIILM YLERQANKDE NIKKIINYQT EEKNKNKQSK WQKLWKAVLE
301: VDLFGLILLG VGWSILLLPF SLTSYAKNGW KNPSMIAMMV VGGVILIAYS GYEMFIAPYP
361: SCPRRVMNRT FITAVIIDFF YYLAGYLQSM YFTTYTWILY DWSYRDWTYF NNTMTIALCV
421: FGVFAGAMHR VFHRYKYLQI IGLVIKIVGY GILIRPNFAA TGKVDLAWSL ILIGMGGSFS
481: VVGSQVSCQA SVPHQDLAIA SSLLPLYTNI GGAIGAAIAS PIFSNKVPKY LREYLPSSIN
541: DTQVYNFYSD SSLIREYPVG TEIRDGAIKA YSRSMFFLLV PAVSLSFIPL AAAFWQSNFY
601: LGNQQNAVEG DQDHKKKGDK ETTQEEKIII