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|---|---|
| Accession Number: | Q86VW1 |
| Protein Name: | Solute carrier family 22 member 16 |
| Length: | 577 |
| Molecular Weight: | 64614.00 |
| Species: | [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | (R)-carnitine, carnitine |
Cross database links:
| RefSeq: | NP_149116.2 |
|---|---|
| Entrez Gene ID: | 85413 |
| Pfam: | PF00083 |
| OMIM: |
608276 gene |
| KEGG: | hsa:85413 hsa:85413 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015226
F:carnitine transporter activity
GO:0046717
P:acid secretion
GO:0015879
P:carnitine transport
GO:0030154
P:cell differentiation
GO:0007275
P:multicellular organismal development
GO:0007338
P:single fertilization
GO:0030317
P:sperm motility
GO:0007283
P:spermatogenesis
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References (18)[1] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.” Eraly S.A.et.al. 12372408 [2] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.” Gong S.et.al. 12384147 [3] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.” Enomoto A.et.al. 12089149 [4] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.” Okabe M.et.al. 15963465 [5] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [8] “Expression of organic cation transporter SLC22A16 in human endometria.” Sato N.et.al. 17197897 [9] “Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.” Ota K.et.al. 17581421 [10] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.” Eraly S.A.et.al. 12372408 [11] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.” Gong S.et.al. 12384147 [12] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.” Enomoto A.et.al. 12089149 [13] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.” Okabe M.et.al. 15963465 [14] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH VCRPPGNVSQ 61: VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR CSRNKRENTS SLGYEYTGSK 121: KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG 181: RRVVLWATSS SMFLFGIAAA FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT 241: WASVHLHSFF AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR 301: YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF YNWSITKRTL 361: TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP AYTFVCIAMD KVGRRTVLAY 421: SLFCSALACG VVMVIPQKHY ILGVVTAMVG KFAIGAAFGL IYLYTAELYP TIVRSLAVGS 481: GSMVCRLASI LAPFSVDLSS IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA 541: KLESENESKS SKLLLTTNNS GLEKTEAITP RDSGLGE