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2.A.1.19.17
Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate).  Activated by tumorigeneic mutations in this antitumor gene to promote apoptosis (AbuAli and Grimm 2014).  Functions in urate reabsorption (Prestin et al. 2014). Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 have been examined at the atomic-scale (Janaszkiewicz et al. 2023).

Accession Number:Q9Y226
Protein Name:ORCTL-3 aka SLC22A13
Length:551
Molecular Weight:60862.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate p-aminohippuric acid, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, lactate, nicotinate

Cross database links:

RefSeq: NP_004247.2   
Entrez Gene ID: 9390   
Pfam: PF00083   
OMIM: 604047  gene
KEGG: hsa:9390    hsa:9390   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015101 F:organic cation transmembrane transporter ac...
GO:0015695 P:organic cation transport
GO:0015101 F:organic cation transmembrane transporter activity

References (8)

[1] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[2] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[6] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC AVAWVKNHTF 
61:	NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS HRFNETQPCD MGWEYPENRL 
121:	PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV GTLMFGPLCD RIGRKATILA QLLLFTLIGL 
181:	ATAFVPSFEL YMALRFAVAT AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL 
241:	AGLAYGFRNW RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR 
301:	KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG LSLQVGDFGL 
361:	DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG GLMCIIIIFI PADLPVVVTM 
421:	LAVVGKMATA AAFTISYVYS AELFPTILRQ TGMGLVGIFS RIGGILTPLV ILLGEYHAAL 
481:	PMLIYGSLPI VAGLLCTLLP ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS 
541:	PGVAFVSSTY F