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2.A.1.19.18
Oranic anion transporter, Oat7 (exchanges sulfate conjugates (steroids) and other anions for butyrate) (Shin et al., 2007).  SLC22A9 and SLC29A2 are transporters mediating cellular uptake of 3,5,3'-Triiodothyroacetic acid (TRIAC), a T3-receptor agonist pharmacologically used in patients to mitigate T3 resistance. SLC22A9 encodes the organic anion transporter 7 (OAT7), a sodium-independent organic anion transporter expressed in the plasma membrane in brain, pituitary, liver, and other organs. Competition with the SLC22A9/OAT7 substrate estrone-3-sulfate reduced 125I-TRIAC uptake. SLC29A2 encodes the equilibrative nucleoside transporter 2 (ENT2), which is ubiquitously expressed, including the pituitary and brain. Coincubation with the SLC29A2/ENT2 inhibitor nitrobenzyl-6-thioinosine reduced 125I-TRIAC uptake. Moreover, ABCD1, an ATP-dependent peroxisomal pump, was identified as a 125I-TRIAC exporter in transfected MDCK1 cells (Becker et al. 2024).

Accession Number:Q8IVM8
Protein Name:Oat7
Length:553
Molecular Weight:62169.00
Species:Homo sapiens [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate steroid, butyrate, estrone 3-sulfate

Cross database links:

RefSeq: NP_543142.2   
Entrez Gene ID: 114571   
Pfam: PF07690   
OMIM: 607579  gene
KEGG: hsa:114571    hsa:114571   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport

References (10)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Isolation of a family of organic anion transporters from human liver and kidney.”  Sun W.et.al.   11327718
[5] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Isolation of a family of organic anion transporters from human liver and kidney.”  Sun W.et.al.   11327718
[10] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

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FASTA formatted sequence 
1:	MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW VHILDNDTVS 
61:	DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH LNGTFPNTSD ADMEPCVDGW 
121:	VYDRISFSST IVTEWDLVCD SQSLTSVAKF VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY 
181:	LQVAIVGTCA ALAPTFLIYC SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP 
241:	SGIAFMTLAG LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR 
301:	KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR ISLLSFTRFA 
361:	NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA LKYMNRRASQ MLLMFLLAIC 
421:	LLAIIFVPQE MQTLREVLAT LGLGASALAN TLAFAHGNEV IPTIIRARAM GINATFANIA 
481:	GALAPLMMIL SVYSPPLPWI IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE 
541:	PKQEDPRVEV TQF