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2.A.1.19.19
The rat kidney basolateral potential-driven symport carrier, Oct2 (transports tetraethylammonium and many other organic cations) (Sweet and Pritchard 1999).  A cysteyl residue critical for substrate binding and transport has been identified (Sturm et al. 2007). Subtype-specific affinity of rat organic cation transporters rOCT1 and rOCT2 for corticosterone depends on three amino acids within the substrate binding region (Gorboulev et al. 2005).

Accession Number:Q9R0W2
Protein Name:Solute carrier family 22 member 2
Length:555
Molecular Weight:62343.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate organic cation, tetraethylammonium

Cross database links:

RefSeq: NP_113772.1   
Entrez Gene ID: 29503   
Pfam: PF00083   
KEGG: rno:29503   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0015220 F:choline transmembrane transporter activity
GO:0015651 F:quaternary ammonium group transmembrane tra...
GO:0015697 P:quaternary ammonium group transport
GO:0055085 P:transmembrane transport

References (12)

[1] “cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.”  Okuda M.et.al.   8702418
[2] “Cloning and characterization of two human polyspecific organic cation transporters.”  Gorboulev V.et.al.   9260930
[3] “Selective substrates for non-neuronal monoamine transporters.”  Gruendemann D.et.al.   10385678
[4] “Transport of monoamine transmitters by the organic cation transporter type 2, OCT2.”  Grundemann D.et.al.   9812985
[5] “Hormonal regulation of organic cation transporter OCT2 expression in rat kidney.”  Urakami Y.et.al.   10812069
[6] “Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules.”  Sugawara-Yokoo M.et.al.   11083459
[7] “Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat.”  Yonezawa A.et.al.   16242669
[8] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.”  Kimura N.et.al.   16272756
[9] “A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.”  Tahara H.et.al.   16006492
[10] “Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.”  Sturm A.et.al.   17567940
[11] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.”  Yokoo S.et.al.   17582384
[12] “Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (slc22a2) and rat multidrug and toxin extrusion 1 (slc47a1) in ischemia/reperfusion-induced acute kidney injury.”  Matsuzaki T.et.al.   18180268

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSTVDDILEH IGEFHLFQKQ TFFLLALLSG AFTPIYVGIV FLGFTPDHHC WSPGAAKLSQ 
61:	RCGWSQAEEL NYTVPGLGPS DEASFLSQCM RYEVDWNQST LDCVDPLSSL AADRNQLPLG 
121:	PCEHGWVYNT PGSSIVTEFN LVCAHSWMLD LFQSVVNVGF FIGAMMIGYL ADRFGRKFCL 
181:	LVTILINAIS GALMAISPNY AWMLVFRFLQ GLVSKAGWLI GYILITEFVG LGYRRMVGIC 
241:	YQIAFTVGLL ILAGVAYVIP NWRWLQFAVT LPNFCFLLYF WCIPESPRWL ISQNKIVKAM 
301:	KIIKHIAKKN GKSVPVSLQN LTPDEDAGKK LNPSFLDLVR TPQIRKHTLI LMYNWFTSSV 
361:	LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFIIILTIDR VGRRYPWAVS NMVAGAACLA 
421:	SVFIPDDLQW LKITIACLGR MGITMAYEMV CLVNAELYPT YIRNLGVLVC SSMCDIGGII 
481:	TPFLVYRLTD IWMEFPLVVF AVVGLVAGAL VLLLPETKGK ALPETIEDAE NMQRPRKKKE 
541:	KRIYLQVKQA DRPLS