TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.19.24
Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) of 556 aas and 12 TMSs.  Induction of astrocytic Slc22a3 (EMT) regulates sensory processing through histone serotonylation (Sardar et al. 2023).

Accession Number:O75751
Protein Name:Solute carrier family 22 member 3
Length:556
Molecular Weight:61280.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate monoamine molecular messenger

Cross database links:

Entrez Gene ID: 6581   
Pfam: PF07690   
KEGG: hsa:6581   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005329 F:dopamine transmembrane transporter activity
GO:0015651 F:quaternary ammonium group transmembrane transporter activity
GO:0019534 F:toxin transporter activity
GO:0051615 P:histamine uptake
GO:0032098 P:regulation of appetite

References (3)

[1] “Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.”  Gruendemann D.et.al.   10196521
[2] “Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.”  Verhaagh S.et.al.   9933568
[3] “Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.”  Wu X.et.al.   10966924

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA 
61:	ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR 
121:	SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG 
181:	RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR 
241:	IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK 
301:	GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT 
361:	SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA 
421:	CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG 
481:	GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS 
541:	CKCGRNKKTP VSRSHL