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|---|---|
| Accession Number: | O15245 |
| Protein Name: | Solute carrier family 22 member 1 |
| Length: | 554 |
| Molecular Weight: | 61154.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Basolateral cell membrane1 / Multi-pass membrane protein2 |
| Substrate | amino acid, polyamine |
Cross database links:
| Entrez Gene ID: | 6580 |
|---|---|
| Pfam: | PF00083 |
| KEGG: | hsa:6580 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0005277
F:acetylcholine transmembrane transporter activity
GO:0005329
F:dopamine transmembrane transporter activity
GO:0005333
F:norepinephrine transmembrane transporter activity
GO:0015101
F:organic cation transmembrane transporter activity
GO:0015651
F:quaternary ammonium group transmembrane transporter activity
GO:0008513
F:secondary active organic cation transmembrane transporter activity
GO:0006855
P:drug transmembrane transport
GO:0048241
P:epinephrine transport
GO:0010248
P:establishment or maintenance of transmembrane electrochemical gradient
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References (18)[1] “Cloning and characterization of two human polyspecific organic cation transporters.” Gorboulev V.et.al. 9260930 [2] “Cloning and functional expression of a human liver organic cation transporter.” Zhang L.et.al. 9187257 [3] “Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1).” Hayer M.et.al. 11388889 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).” Zhang L.et.al. 9655880 [8] “Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides.” van Montfoort J.E.et.al. 11408531 [9] “Regulation of the human organic cation transporter hOCT1.” Ciarimboli G.et.al. 15389554 [10] “Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).” Mueller J.et.al. 16263091 [11] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.” Kimura N.et.al. 16272756 [12] “The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.” Saborowski M.et.al. 16436500 [13] “Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.” Amphoux A.et.al. 16581093 [14] “The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.” Dias V.et.al. 17635184 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ 61: RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP 121: CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL 181: GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY 241: QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK 301: IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL 361: YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM 421: IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT 481: PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN 541: TIYLKVQTSE PSGT