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|---|---|
| Accession Number: | O15244 |
| Protein Name: | Solute carrier family 22 member 2 |
| Length: | 555 |
| Molecular Weight: | 62581.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Entrez Gene ID: | 6582 |
|---|---|
| Pfam: | PF00083 |
| KEGG: | hsa:6582 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0015101
F:organic cation transmembrane transporter activity
GO:0007589
P:body fluid secretion
GO:0042136
P:neurotransmitter biosynthetic process
GO:0007269
P:neurotransmitter secretion
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References (23)[1] “Cloning and characterization of two human polyspecific organic cation transporters.” Gorboulev V.et.al. 9260930 [2] “cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.” Urakami Y.et.al. 12089365 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The DNA sequence and analysis of human chromosome 6.” Mungall A.J.et.al. 14574404 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.” Gruendemann D.et.al. 10942111 [7] “Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.” Busch A.E.et.al. 9687576 [8] “Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.” Urakami Y.et.al. 11758759 [9] “Gene expression levels and immunolocalization of organic ion transporters in the human kidney.” Motohashi H.et.al. 11912245 [10] “Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).” Grundemann D.et.al. 12538837 [11] “Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).” Motohashi H.et.al. 15496291 [12] “Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.” Ciarimboli G.et.al. 16314463 [13] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.” Kimura N.et.al. 16272756 [14] “A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.” Tahara H.et.al. 16006492 [15] “Metformin transport by renal basolateral organic cation transporter hOCT2.” Kimura N.et.al. 15783073 [16] “Characterization of regulatory mechanisms and states of human organic cation transporter 2.” Biermann J.et.al. 16394027 [17] “Organic cation transporters are determinants of oxaliplatin cytotoxicity.” Zhang S.et.al. 16951202 [18] “Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.” Okuda M.et.al. 17072098 [19] “Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).” Yonezawa A.et.al. 16914559 [20] “Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.” Yokoo S.et.al. 17582384 [21] “The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.” Bottalico B.et.al. 17393420 | |
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1: MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS 61: LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG 121: PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL 181: LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF 241: YQVAYTVGLL VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 301: RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV 361: LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA 421: SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII 481: TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE 541: KMIYLQVQKL DIPLN