| |
|---|---|
| Accession Number: | Q4U2R8 |
| Protein Name: | Solute carrier family 22 member 6 |
| Length: | 563 |
| Molecular Weight: | 61816.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | organic anion, methotrexate, adefovir, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, acyclovir |
Cross database links:
| Entrez Gene ID: | 9356 |
|---|---|
| Pfam: | PF00083 |
| KEGG: | hsa:9356 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0005901
C:caveola
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0043234
C:protein complex
GO:0005452
F:inorganic anion exchanger activity
GO:0008514
F:organic anion transmembrane transporter activity
GO:0015347
F:sodium-independent organic anion transmembrane transporter activity
GO:0015742
P:alpha-ketoglutarate transport
GO:0097254
P:renal tubular secretion
GO:0031427
P:response to methotrexate
GO:0043252
P:sodium-independent organic anion transport
| |
References (17)[1] “Cloning of a human renal p-aminohippurate transporter, hROAT1.” Reid G.et.al. 9762842 [2] “Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.” Hosoyamada M.et.al. 9887087 [3] “Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.” Lu R.et.al. 9950961 [4] “Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).” Race J.E.et.al. 10049739 [5] “The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.” Cihlar T.et.al. 10462545 [6] “Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.” Bahn A.et.al. 10964714 [7] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Interaction of cysteine conjugates with human and rabbit organic anion transporter 1.” Groves C.E.et.al. 12538807 [10] “Role of glycosylation in the organic anion transporter OAT1.” Tanaka K.et.al. 14749323 [11] “Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.” Hong M.et.al. 15145940 [12] “Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).” Srimaroeng C.et.al. 15644426 [13] “Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.” Tahara H.et.al. 15846473 [14] “A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.” Perry J.L.et.al. 17038320 [15] “Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.” Mizuno N.et.al. 17502342 [16] “Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).” Bleasby K.et.al. 15914676 [17] “Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].” Xu G.et.al. 16164626
| |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR PPADANLSKN 61: GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG ATEPCTDGWI YDNSTFPSTI 121: VTEWDLVCSH RALRQLAQSL YMVGVLLGAM VFGYLADRLG RRKVLILNYL QTAVSGTCAA 181: FAPNFPIYCA FRLLSGMALA GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV 241: AYAVPHWRHL QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE 301: GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS FAYYGLVMDL 361: QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA ALLLAGICIL LNGVIPQDQS 421: IVRTSLAVLG KGCLAASFNC IFLYTGELYP TMIRQTGMGM GSTMARVGSI VSPLVSMTAE 481: LYPSMPLFIY GAVPVAASAV TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT 541: RQQQEHQKYM VPLQASAQEK NGL