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2.A.1.19.34
Multispecific drug transporter, solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3).  Both OAT1 and OAT3 of humans are inhibited by caffeic acid (Ki ~ 17 μM) (Uwai et al. 2011; Wu et al. 2013).  It is the principal uptake system for steviol glucuronide (SVG), the major metabolite derived from steviol, the aglycone of stevioside and rebaudioside A (Wang et al. 2015).  Also functions in urate uptake from the circulation across the basolateral membrane of renal tubular cells (Prestin et al. 2014). Inhibition of the proteasome, but not the lysosome, upregulates organic anion transporter 3 (Fan et al. 2022). See also 2.A.1.19.9.

Accession Number:Q8TCC7
Protein Name:Solute carrier family 22 member 8
Length:542
Molecular Weight:59856.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate drug

Cross database links:

Entrez Gene ID: 9376   
Pfam: PF00083   
KEGG: hsa:9376   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0008514 F:organic anion transmembrane transporter activity
GO:0015651 F:quaternary ammonium group transmembrane transporter activity
GO:0034635 P:glutathione transport
GO:0031427 P:response to methotrexate
GO:0009636 P:response to toxin

References (9)

[1] “Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).”  Race J.E.et.al.   10049739
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Gene expression levels and immunolocalization of organic ion transporters in the human kidney.”  Motohashi H.et.al.   11912245
[4] “Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux.”  Bakhiya A.et.al.   14586168
[5] “Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).”  Srimaroeng C.et.al.   15644426
[6] “Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.”  Tahara H.et.al.   15846473
[7] “Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.”  Tahara H.et.al.   16455804
[8] “Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.”  Nishizato Y.et.al.   12811365
[9] “The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.”  Erdman A.R.et.al.   16291576

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW 
61:	VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK 
121:	LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR 
181:	FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL 
241:	TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 
301:	LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI 
361:	IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG 
421:	CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI 
481:	TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG 
541:	SS