2.A.1.19.5
The putative apical polyspecific organic cation transporter (cation:H+ or cation:cation antiporter), Oct2 (substrates include monoamine neurotransmitters such as dopamine, noradrenaline, adrenaline and 5-hydroxytryptamine) (Oct2 exhibits some properties of an ion channel with an inner diameter of ~4 Å. Selectivity: Cs+ > Rb+ > K+ > Na+ %u2248 Li+ (Schmitt and Koepsell, 2005)) Chloride dependent, but a single mutation (R466K) abolishes this dependency (Rizwan et al., 2007). Also transports ochratoxin (Rizwan et al., 2007) and cisplatin and oxaliplatin (Yonezama et al., 2006).
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| Accession Number: | O02713 |
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| Protein Name: | Oct2 aka OCT2P |
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| Length: | 554 |
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| Molecular Weight: | 61990.00 |
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| Species: | Sus scrofa (Pig) [9823] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lithium(1+), sodium(1+), potassium(1+), rubidium(1+), caesium(1+), cisplatin, ochratoxin A, oxaliplatin |
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| RefSeq: |
NP_999067.1
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| Entrez Gene ID: |
396936
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| Pfam: |
PF00083
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| KEGG: |
ssc:396936
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[1] “Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells.” Grundemann D. et.al. 9099681
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1: MLTVDDILEH TGEFNFFQKQ TFFLLALLSA AFTPIYVGIV FLGFIPDHRC RSPGVAELSQ
61: RCGWSLAEEL NYTVPGPGPA GQAFPRQCRR YEVDWNQSTL GCVDPLAGLA ANSSHLPLGP
121: CRYGWVYDTP GSSIVTEFDL VCANSWLLDL FQSAVNVGFF IGSVGIGYIA DRFGRKLCLL
181: LTILINAVSG VLMAISPTYT WMLVFRLIQG LVSKAGWMIG YILITEFVGL SYRRTVGIFY
241: QVAFTFGLLV LAGVAYALPH WRWLQFTVTL PNFCFLFYYW CVPESPRWLI SQNKNAKAMS
301: IIKHIAKKNG KSLPASLQSL RPDEEVGEKL KPSFLDLVRT PQIRKHTLIL MYNWFTSAVL
361: YQGLVMHMGL AGSNLYLDFF YSALVEFPAA LLILLTIDRL GRRHPWAASN VVAGAACLAS
421: VFIPEDPHWL RITVLCLGRM GITMAYEMVC LVNAELYPTF IRNLGVLVCS SMCDIGGIIT
481: PFLVYRLTDI WHELPLVVFA VVGLIAGGLV LLLPETKGKT LPETIEEAET MRRPRKNKEK
541: IIYLQVKKLD IPPN