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Accession Number: | O88446 |
Protein Name: | Oct3 aka SLC22A3 |
Length: | 551 |
Molecular Weight: | 61050.00 |
Species: | Rattus norvegicus (Rat) [10116] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | dopamine, N-methyl-4-phenylpyridinium |
Cross database links:
RefSeq: | NP_062103.1 |
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Entrez Gene ID: | 29504 |
Pfam: | PF00083 |
KEGG: | rno:29504 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005329
F:dopamine transmembrane transporter activity
GO:0005515
F:protein binding
GO:0015651
F:quaternary ammonium group transmembrane tra...
GO:0019534
F:toxin transporter activity
GO:0015872
P:dopamine transport
GO:0015697
P:quaternary ammonium group transport
GO:0055085
P:transmembrane transport
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References (2)[1] “Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta.” Kekuda R.et.al. 9632645 [2] “Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain.” Wu X.et.al. 9830022
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW CRGPRATALA 61: ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEDTNT SSELSCDPLA AFPNRSAPLV 121: PCSGDWRYVE THSTIVSQFD LVCGNAWMLD LTQAILNLGF LAGAFTLGYA ADRYGRLIVY 181: LISCFGVGIT GVVVAFAPNF SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV 241: IQMFFTLGII ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL 301: QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM FAWFTSAVVY 361: QGLVMRLGLI GGNLYMDFFI SGLVELPGAL LILLTIERLG RRLPFAASNI VAGVSCLVTA 421: FLPEGIPWLR TTVATLGRLG ITMAFEIVYL VNSELYPTTL RNFGVSLCSG LCDFGGIIAP 481: FLLFRLAAIW LELPLIIFGI LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR 541: KKKTQVSTSN V