2.A.1.2.100
Bcr/CflA family drug resistance efflux transporter of 389 aas and 12 TMSs. Multidrug-resistance in S. aureus is inhibited by the endocannabinoid, anandamide (Sionov et al. 2022). Butyrolactone I enhances the efficacy of gentamycin in methicillin-resistant S. aureus (Jiang et al. 2024).
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| Accession Number: | Q9F4G1 |
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| Protein Name: | Drug resistance transporter, Bcr/CflA subfamily |
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| Length: | 402 |
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| Molecular Weight: | 43823.00 |
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| Species: | Staphylococcus aureus [1280] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MNDLTHFNKR SPIFIIILGS LTAIGALSID MFLPGLPDIR HDFQTTTSNA QLTLSMFMIG
61: LAFGNLFAGP ISDSTGRRKP LIIAMIIFTL ASLGIVFVHN IWLMVALRFL QGVTGGAAAV
121: ISRAIASDMY SGNELTKFMA LLMLVNGIAP VVAPTIGGII LNYSVWRMVF VILTIFGFVM
181: VIGSLLKVPE SLTVTNRESS SGLKTMFKNF KILLKTPRFV LPMLIQGMTF VILFTYISAS
241: PFIIQKIYGM TAIQFSWMFA GIGITLIISS QLTGYLVDFI DSQKLMRGMT MIQIIGVILV
301: TIVLLNHWNF WILAIGFIIL IAPVTGVATL GFTIAMDESS SGRGSSSSLL GLVQFLFGGV
361: ASPLVGVKGE DNPIPYIIII IATAVILIIL QIYNMKVFKT NR