2.A.1.2.115
Multidrug resistance MDR exporter of 583 aas and 12 TMSs. It is involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole and ketoconazole as well as to quinidine   (Costa et al. 2013; Costa et al. 2016).  It also plays a role in biofilm formation. Compared to the wild type, the C. glabrata ∆qdr2 mutant showed lower adhesion activity and higher fluconazole susceptibility when assessed as a biofilm. The mutant also showed decreased metabolic activity during biofilm formation and grew more slowly under neutral-basic pH conditions. The qdr2 deletion in C. glabrata resulted in an impaired ability to maintain pH homeostasis, which led in turn to a reduction of cell growth and of adherence to an artificial matrix (Widiasih Widiyanto et al. 2019). Mitochondrion-targeted antifungal drugs have been reviewed (Qin et al. 2023).