2.A.1.2.118
Na+ (K+ or Li+)/H+ antiporter and multidrug:Na+ anitporter, MdrP of 424 aas and 12 TMSs. It exports ethidium and norfloxacin in exchange for Na+ taken up (Abdel-Motaal et al. 2018). D223 acts as a key determinant in the Na+ translocation coupled to norfloxacin efflux (R. Zhang, Abdel-Motaal et al, 2020).
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| Accession Number: | WP_068464567.1 |
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| Protein Name: | WP_068464567.1 MFS transporter [Planococcus maritimus] |
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| Length: | 425 |
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| Molecular Weight: | |
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| Species: | Planococcus maritimus [192421] |
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| Number of TMSs: | 12 |
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| Substrate |
lithium(1+), sodium(1+), potassium(1+), norfloxacin, ethidium |
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1: MKIKDWNRSL KVRLVGEFFM NTSFWMVFPF LAIYFAEEFG KGLAGMLLII SQIFSVAANL
61: FGGYFADRFG RKRMLVSAAV AQGFAFLLFA LANSPWLTSP ELSFVAFTLA GMCGSLYWPA
121: SQAMIADVIP EKYRSDVFAV FYTTLNIAVV IGPLFGAVLF FSYRFELLLT VAIISVLLGL
181: LLRFYTEETL SAEVLEKWKE GNATGWRGAL LTQVKDYGII LKDRVFLLFV IAGILGAQTF
241: MQLDLVIPVY LKETIDRQTI LDFLGREWSV TGETSFGILL AENGLIVALL TVVITRWMTK
301: FPEKWVFFFS ALLFGLSMAI FPMTSWFWIF FVAMAVFTFA ELMVVGLQQS FISKLAPESM
361: RGQYFAAASL RYTIGRMIAP ISIPMTAWFG FGWTFIILGS FAVLSGFVYL WMFHLYDKRT
421: VANI