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2.A.1.2.12
Chromaffin granule monoamine (and drug) transporter, VAT1. It is involved in the transport of biogenic monoamines such as serotonin from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells (Essand et al. 2005). It is strongly inhibited by reserpine, and to a lesser extent by ketanserin and fenfluramine, but not by tetrabenazine (Erickson et al. 1996).  Fine-tuning novel monoamine reuptake inhibitor selectivities has been acieved through manipulation of inhibitor stereochemistry (chirality) (Kalaba et al. 2023).

Accession Number:P54219
Protein Name:VMT1 aka VAT1 aka SLC18A1 aka VMAT1
Length:525
Molecular Weight:56257.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate monoamine molecular messenger, drug

Cross database links:

RefSeq: NP_001129163.1    NP_001135796.1    NP_001135797.1    NP_003044.1   
Entrez Gene ID: 6570   
Pfam: PF07690   
OMIM: 193002  gene
KEGG: hsa:6570    hsa:6570   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0015238 F:drug transmembrane transporter activity
GO:0008504 F:monoamine transmembrane transporter activity
GO:0015893 P:drug transport
GO:0015844 P:monoamine transport
GO:0006836 P:neurotransmitter transport
GO:0055085 P:transmembrane transport
GO:0070083 C:clathrin sculpted monoamine transport vesicle membrane
GO:0015222 F:serotonin transmembrane transporter activity
GO:0071285 P:cellular response to lithium ion
GO:0006855 P:drug transmembrane transport
GO:0051612 P:negative regulation of serotonin uptake
GO:0033603 P:positive regulation of dopamine secretion
GO:0051610 P:serotonin uptake

References (2)

[1] “Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.”  Erickson J.D.et.al.   8643547
[2] “Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.”  Erickson J.D.et.al.   8643547

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS 
61:	LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA 
121:	HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS 
181:	TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL 
241:	LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP 
301:	YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA 
361:	NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL 
421:	RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS 
481:	PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE