2.A.1.2.123
Fluconazole resistance protein 1, Flu1 of 610 aas and 12 TMSs. It mediates resistance to structurally and functionally unrelated compounds
including cycloheximide but also azoles such as fuconazole,
ketoconazole and itraconazole (Calabrese et al. 2000). It mediates efflux of histatin 5, a salivary human antimicrobial peptide, and
is responsible for reduction of its toxicity in C.albicans (Li et al. 2013, Hampe et al. 2017). Mutations in the Erg251 ergosterol biosynthetic enzyme can also give rise to azole resistance (Zhou et al. 2024). Batzelladine D, a marine natural product, reverses the fluconazole resistance phenotype mediated by transmembrane transporters in Candida albicans. It also interferes with biofilm formation (Domingos et al. 2024).
|
| Accession Number: | G1UB37 |
|---|
| Protein Name: | Major facilitator superfamily multidrug transporter FLU1 |
|---|
| Length: | 610 |
|---|
| Molecular Weight: | 67607.00 |
|---|
| Species: | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [237561] |
|---|
| Number of TMSs: | 11 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
azole, cycloheximide, antifungal agent, drug, fluconazole |
|---|
1: MNNNTNSNHN DIAPEATITQ NTTTSVSNDE LQHITNNNNV NVQSYVGPTD SVESSSNTAD
61: EENEINSFNA QNVKDYEANV GGELPPDDEL SRIESNTELS RRATRSIMNT ESLLRTASQS
121: SKPLPPMGGG KEYPPMLGSR DPYVVAFDGP DDPDHPHNYP TWKKILYCAS VGLAALSVSM
181: GSAMFSQASA DIMQIYHIGW TPATLTTSLF VFGFASGPVI YGPLSELFGR KLVMVPSCLG
241: YVCFSFAVAT AKDIQTIMIC RFFAGFIGAA PLVVAPAVMA DMFNNRYRGT AIAIFSMLLF
301: GGPMLAPILG AFTVKNSALG WRWTSYFCGI IGSLALFMNT FLLQETHHPL ILTRRAEELR
361: RRTGNWGIYA PHEELKLSMK EIVENNIARP LKMLFTEPIL FLVSLYNAFI YGMLYLFLTA
421: IPLIFLGEYH FVQGVAELPY LAMLIGILIG GGMIMLFEKR YIKAMEDNGG KIIPEKRLEP
481: MMVGGFTFVI GIFWLGWTGN YPQHVHWIVP VIGAAFVGNG LMLIFLPCFN YIIDCYLLYA
541: ATALAGNTFI RSAFGAVFPL FARQMFTNLT IKWASTLLGC IGILLLPMPF VFYYYGKSLR
601: HKSKFAFVLE