2.A.1.2.126 MFS permease of 405 aas and 12 TMSs, KpsrMFS (He et al. 2024). This efflux pump is a
proton-driven transporter that can reduce the intracellular
tetracycline concentration. In normal conditions, the expression of kpsrmfs was at a low level, while artificial overexpression of it led to
increased endogenous reactive oxygen species (ROS) production. By comparing the functions of adjacent genes of kpsrmfs, another four genes that can confer similar
phenotypes, indicating a special regulon that regulates cell growth..
|
Accession Number: | QPN10789.1 |
Protein Name: | QPN10789.1 MFS transporter [Klebsiella pneumoniae] |
Length: | 406 |
Molecular Weight: | |
Species: | Klebsiella pneumoniae [573] |
Number of TMSs: | 12 |
Substrate |
hydron, antimicrobial agent |
---|
1: MSLRSLRALC LTSFFIADVR DGLGPFLGIF LTQRHWQAED IGLLMSVGGI AGLLATLPAG
61: FITDSSRHKR LLLAGVCLVI TLTTLLLWFS QKTSVVALSQ VASGICAAFV GPLIAGITLG
121: LARQRGFSAQ MGKNEAFNHA GNFFTALMAG AIAWYWGIGG IFILMACTTL LTLVALLAIR
181: GGDIDDDAAR GIEAASTPSL PGFAILFRHT PLLIAGVTLM LFHLANAALL PMLSMRIAAA
241: PGHLNPGLFA AATVIISQVV MIPVAIRVAG SIDKYGYWRC ILLALLIMPI RAALAASSDA
301: PAMMVPVQIL DGLAAGILGV AVPSFIVSLL RGSGHVNAGQ SVVMLMQGAG AAMSPALTGS
361: IAGHYSYATA FGVLSVIAIV ALMVWWRSAP LLTVSASPPV GESGQ