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2.A.1.2.15 Arabinose (but not xylose) and isopropyl β-D-thio-galactopyranoside:H⁺ antiporter, YdeA (Koita and Rao 2012). Overexpression of the gene for YdeA allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).
Accession Number:	P31122
Protein Name:	YdeA aka SOTB aka B1528
Length:	396
Molecular Weight:	42538.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron, oligosaccharide, arabinose

Structure:
RefSeq:	AP_002149.1 NP_416045.1
Entrez Gene ID:	947218
Pfam:	PF07690
BioCyc:	EcoCyc:YDEA-MONOMER ECOL168927:B1528-MONOMER
KEGG:	ecj:JW1521 eco:b1528
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015144 F:carbohydrate transmembrane transporter acti... GO:0015292 F:uniporter activity GO:0008643 P:carbohydrate transport GO:0055085 P:transmembrane transport
References (7) [1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.” Cohen S.P.et.al. 8383113 [5] “Transcriptional activation of ydeA, which encodes a member of the major facilitator superfamily, interferes with arabinose accumulation and induction of the Escherichia coli arabinose PBAD promoter.” Bost S.et.al. 10094697 [6] “Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside.” Carole S.et.al. 10438792 [7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
6KKI 6KKJ 6KKK 6KKL

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTTNTVSRKV AWLRVVTLAV AAFIFNTTEF VPVGLLSDIA QSFHMQTAQV GIMLTIYAWV 
61:	VALMSLPFML MTSQVERRKL LICLFVVFIA SHVLSFLSWS FTVLVISRIG VAFAHAIFWS 
121:	ITASLAIRMA PAGKRAQALS LIATGTALAM VLGLPLGRIV GQYFGWRMTF FAIGIGALIT 
181:	LLCLIKLLPL LPSEHSGSLK SLPLLFRRPA LMSIYLLTVV VVTAHYTAYS YIEPFVQNIA 
241:	GFSANFATAL LLLLGGAGII GSVIFGKLGN QYASALVSTA IALLLVCLAL LLPAANSEIH 
301:	LGVLSIFWGI AMMIIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA LVGNQVSLHW 
361:	SMSMIGYVGA VPAFAALIWS IIIFRRWPVT LEEQTQ

2.A.1.2.15
Arabinose (but not xylose) and isopropyl β-D-thio-galactopyranoside:H⁺ antiporter, YdeA (Koita and Rao 2012). Overexpression of the gene for YdeA allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.1.2.15Arabinose (but not xylose) and isopropyl β-D-thio-galactopyranoside:H+ antiporter, YdeA (Koita and Rao 2012). Overexpression of the gene for YdeA allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.1.2.15
Arabinose (but not xylose) and isopropyl β-D-thio-galactopyranoside:H⁺ antiporter, YdeA (Koita and Rao 2012). Overexpression of the gene for YdeA allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).