| |
|---|---|
| Accession Number: | Q07824 |
| Protein Name: | TPO1 aka YLL028w |
| Length: | 586 |
| Molecular Weight: | 64272.00 |
| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, spermidine, spermine, putrescine, paraquat, mitoguazone |
Cross database links:
| DIP: | DIP-1706N |
|---|---|
| RefSeq: | NP_013072.1 |
| Entrez Gene ID: | 850631 |
| Pfam: | PF07690 |
| KEGG: | sce:YLL028W |
Gene Ontology
GO:0033101
C:cellular bud membrane
GO:0016021
C:integral to membrane
GO:0005774
C:vacuolar membrane
GO:0015297
F:antiporter activity
GO:0015238
F:drug transmembrane transporter activity
GO:0042802
F:identical protein binding
GO:0015606
F:spermidine transmembrane transporter activity
GO:0000297
F:spermine transmembrane transporter activity
GO:0015893
P:drug transport
GO:0015847
P:putrescine transport
GO:0015848
P:spermidine transport
GO:0000296
P:spermine transport
GO:0055085
P:transmembrane transport
| |
References (16)[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.” Johnston M.et.al. 9169871 [2] “Identification of a gene for a polyamine transport protein in yeast.” Tomitori H.et.al. 9920864 [3] “Multiple polyamine transport systems on the vacuolar membrane in yeast.” Tomitori H.et.al. 11171066 [4] “Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs.” do Valle Matta M.A.et.al. 11470516 [5] “Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.” Ficarro S.B.et.al. 11875433 [6] “Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.” Kim H.et.al. 12524434 [7] “Localization and function of the yeast multidrug transporter Tpo1p.” Albertsen M.et.al. 12562762 [8] “Global analysis of protein localization in budding yeast.” Huh W.-K.et.al. 14562095 [9] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [10] “Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis.” Shepard K.A.et.al. 13679573 [11] “Exposure of Saccharomyces cerevisiae to acetaldehyde induces sulfur amino acid metabolism and polyamine transporter genes, which depend on Met4p and Haa1p transcription factors, respectively.” Aranda A.et.al. 15066780 [12] “Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation.” Uemura T.et.al. 15637075 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MSDHSPISNK ENHLLPSDSS RSSSSDMHST GTTGTTGVEP VDFTGEGAKY TTATEGNGGA 61: DLAIQRTTTM NSAAESEVNI TRRLTKILTG SVNEPDRVEV DYTNCAPMGG DRPYPPSLPS 121: RDLYEVTFDG PNDPLHPFNW PMKKKVLLCL VLCLDSIAIA MCSSIFASAV PQICEIYHVI 181: EVVAILGITL FVLGFAASPV IYAPLSELYG RKGVLVLSAF GFALFQFAVA TAENLQTIFI 241: CRFFGGFIGA APMAVVPAAF ADMFDTNVRG KAIALFSLGV FVGPILSPVM GSYIAQRTTW 301: RWLEYVVGCF ASAVFVAIVL FFEETHHPTI LVNKAKQMRK QSNNWGIHAA HEDVELSIKD 361: IVQKTVTRPI IMLFVEPLLL FVTIYNSFVY GILYLLLEAY PLVFVEGYGF TENGELPYIA 421: LIIGMMVCAA FIWYMDNDYL KRCRAKGKLV PEARLYAMVI AGTVFPIGIL WFCWTGYYPH 481: KIHWMVPTVG GAFIGFGLMG IFLPCLNYII ESYLLLAASA VAANTFMRSA FGACFPLFAG 541: YMFRGMGIGW AGLLLGLFAA AMIPVPLLFL KYGESIRKKS KYAYAA