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2.A.1.2.20 Broad specificity MDR efflux pump, MdtG (YceE) (under SoxSR control) (Fàbrega et al., 2010). Confer resistance to fosfomycin, fluoroquinolone and many other drugs (Nishino and Yamaguchi 2001). It may also export ectoine and hydroxyectoine (Czech et al. 2022).
Accession Number:	P25744
Protein Name:	YceE aka B1053
Length:	408
Molecular Weight:	43867.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	fluoroquinolone antibiotic, fosfomycin

RefSeq:	AP_001679.1 NP_415571.1
Entrez Gene ID:	945627
Pfam:	PF07690
BioCyc:	EcoCyc:YCEE-MONOMER ECOL168927:B1053-MONOMER
KEGG:	ecj:JW1040 eco:b1053
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015520 F:tetracycline:hydrogen antiporter activity GO:0046677 P:response to antibiotic GO:0015904 P:tetracycline transport GO:0055085 P:transmembrane transport
References (5) [1] “Multicopy suppression: an approach to understanding intracellular functioning of the protein export system.” Ueguchi C.et.al. 1537791 [2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Analysis of a complete library of putative drug transporter genes in Escherichia coli.” Nishino K.et.al. 11566977

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS ALNMWSGIVF 
61:	SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL MGLAQNIWQF LILRALLGLL 
121:	GGFVPNANAL IATQVPRNKS GWALGTLSTG GVSGALLGPM AGGLLADSYG LRPVFFITAS 
181:	VLILCFFVTL FCIREKFQPV SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP 
241:	ILTLYVRELA GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL 
301:	LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS YNQSFRDIGN 
361:	VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR RRIPQVSN

2.A.1.2.20
Broad specificity MDR efflux pump, MdtG (YceE) (under SoxSR control) (Fàbrega et al., 2010). Confer resistance to fosfomycin, fluoroquinolone and many other drugs (Nishino and Yamaguchi 2001). It may also export ectoine and hydroxyectoine (Czech et al. 2022).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.1.2.20Broad specificity MDR efflux pump, MdtG (YceE) (under SoxSR control) (Fàbrega et al., 2010). Confer resistance to fosfomycin, fluoroquinolone and many other drugs (Nishino and Yamaguchi 2001). It may also export ectoine and hydroxyectoine (Czech et al. 2022).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.1.2.20
Broad specificity MDR efflux pump, MdtG (YceE) (under SoxSR control) (Fàbrega et al., 2010). Confer resistance to fosfomycin, fluoroquinolone and many other drugs (Nishino and Yamaguchi 2001). It may also export ectoine and hydroxyectoine (Czech et al. 2022).