2.A.1.2.30
The hippocampus abundant transcript-like 1 protein, HIATL1 or MFSD14B, of 506 aas and 12 TMSs (putative drug exporter) is a SLC18 family member. There is a correlation between a risk for colorectal cancer, alcohol consumption and variants in the 9q22.32/HIATL1 gene (Gong et al. 2016). MFSD14A (HIAT1) and MFSD14B (HIATL1) are in the mouse central nervous system throughout the adult brain (Lekholm et al. 2017). Expression of SLC22A18 regulates oxaliplatin resistance (Kim et al. 2022), and in cases of oxaliplatin resistance due to low SLC22A18 expression, resistance can be overcome by treatment with an ERK inhibitor (Kim et al. 2022). Two ammonia transporters, HIAT1alpha and HIAT1beta, in the American Horseshoe Crab, Limulus polyphemus, have been identified and characterized (Sachs et al. 2022). This gene is associated with milk production in buffalo and sheep breeds, as well as growth of chickens and goats, and drastically affect sperm formation (Luo et al. 2023). The functional InDel polymorphism (rs1089950828) reflects growth traits in domestic sheep populations (Luo et al. 2023).